D
D. W. Burdon
Publications - 11
Citations - 419
D. W. Burdon is an academic researcher. The author has contributed to research in topics: Clostridium difficile toxin A & Clostridium difficile. The author has an hindex of 8, co-authored 11 publications receiving 405 citations.
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Journal ArticleDOI
Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.
Timothy J. Mitchell,Julian M. Ketley,S. C. Haslam,John Stephen,D. W. Burdon,D. C. A. Candy,Daniel R +6 more
TL;DR: Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A, and secreted fluid contained less protein of plasma origin.
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Growth of Clostridium difficile and production of toxins A and B in complex and defined media.
TL;DR: Toxin A production was not inextricably linked to production of toxin B since conditions were found in which only one or other toxin was produced.
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The effects of Clostridium difficile crude toxins and toxin A on ileal and colonic loops in immune and nonimmune rabbits
TL;DR: Rabbits were solidly immunised by parenteral injection of purified Clostridium difficile toxin A such that they resisted an intravenous challenge with a normally lethal dose of toxin A, and there was less fluid accumulation in ligated ileal loops of immune than of non-immune rabbits.
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Biological mode of action of Clostridium difficile toxin A: a novel enterotoxin.
TL;DR: Toxin A is a novel type of histotoxic enterotoxin that induced haemorrhage in both ileal and colonic tissues and is thus a noveltype of HistotoxicEnterotoxin.
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Production and Release of Toxins A and B by Clostridium Difficile
TL;DR: The production and release of toxins A and B by Clostridium difficile during in-vitro culture was investigated and the possible significance of these results in relation to the pathogenesis of pseudomembranous colitis is discussed.