D
Damian C. Crowther
Researcher at University of Cambridge
Publications - 76
Citations - 4719
Damian C. Crowther is an academic researcher from University of Cambridge. The author has contributed to research in topics: Neuroserpin & Familial encephalopathy with neuroserpin inclusion bodies. The author has an hindex of 36, co-authored 76 publications receiving 4294 citations. Previous affiliations of Damian C. Crowther include AstraZeneca & MedImmune.
Papers
More filters
Journal ArticleDOI
Endoplasmic reticulum dysfunction in neurological disease
Benoit D. Roussel,Benoit D. Roussel,Antonina J. Kruppa,Elena Miranda,Damian C. Crowther,David A. Lomas,Stefan J. Marciniak +6 more
TL;DR: By targeting components of these signalling responses, amelioration of their toxic effects and so the treatment of a range of neurodegenerative disorders might become possible.
Journal ArticleDOI
Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease
Damian C. Crowther,Kerri J. Kinghorn,Elena Miranda,Richard M. Page,J.A. Curry,F.A.I. Duthie,David Gubb,David A. Lomas +7 more
TL;DR: This model demonstrates that intracellular accumulation and non-amyloid aggregates of Aβ are sufficient to cause the neurodegeneration of Alzheimer’s disease and provides a platform to dissect the pathways of neurodegenersation in Alzheimer's disease and to develop novel therapeutic interventions.
Journal ArticleDOI
ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
Benedetta Bolognesi,Janet R. Kumita,Teresa P. Barros,Elin K. Esbjörner,Leila M. Luheshi,Damian C. Crowther,Mark R. Wilson,Christopher M. Dobson,Giorgio Favrin,Justin J. Yerbury,Justin J. Yerbury +10 more
TL;DR: This paper showed that prefibrillar aggregates of E22G (arctic) variant of the Aβ1−42 peptide bind strongly to 1-anilinonaphthalene 8-sulfonate and that changes in this property correlate significantly with changes in its cytotoxicity.
ANS binding reveals common features of cytotoxic amyloid species
Benedetta Bolognesi,Janet R. Kumita,Teresa P. Barros,Elin K. Esbjörner,Leila M. Luheshi,Damian C. Crowther,Mark R. Wilson,Christopher M. Dobson,Giorgio Favrin,Justin J. Yerbury,Justin J. Yerbury +10 more
TL;DR: It is shown that prefibrillar aggregates of E22G (arctic) variant of the Abeta(1-42) peptide bind strongly to 1-anilinonaphthalene 8-sulfonate and that changes in this property correlate significantly with changes in its cytotoxicity.
Journal ArticleDOI
Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity
Leila M. Luheshi,Gian Gaetano Tartaglia,Ann-Christin Brorsson,Amol Pawar,Ian E Watson,Fabrizio Chiti,Michele Vendruscolo,David A. Lomas,Christopher M. Dobson,Damian C. Crowther +9 more
TL;DR: These findings provide a quantitative description of the molecular basis for the pathogenicity of Aβ and link directly and systematically the intrinsic properties of biomolecules, predicted in silico and confirmed in vitro, to pathogenic events taking place in a living organism.