D
Danae Campos-Melo
Researcher at University of Western Ontario
Publications - 20
Citations - 566
Danae Campos-Melo is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Guanine nucleotide exchange factor. The author has an hindex of 10, co-authored 19 publications receiving 431 citations. Previous affiliations of Danae Campos-Melo include Robarts Research Institute.
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Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels
TL;DR: The miRNA expression profile is broadly altered in the SC in sALS, with a group of dysregulated miRNAs directly regulate the NFL mRNA 3′UTR suggesting a role in the selective suppression of NFL mRNA in the ALS spinal motor neuron neurofilamentous aggregate formation.
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RNA metabolism in ALS: when normal processes become pathological.
Cristian A. Droppelmann,Danae Campos-Melo,Muhammad Ishtiaq,Kathryn Volkening,Michael J. Strong +4 more
TL;DR: It is examined how the normal process of cellular response to stress leading to RNA stress granule formation might become pathological, resulting in the formation of stable protein aggregates, and the emerging roles of post-translational modifications of RNA binding proteins in the genesis of these aggregates.
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The Integral Role of RNA in Stress Granule Formation and Function.
TL;DR: Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein (RNP) assemblies whose primary function is to promote cell survival by condensing translationally stalled mRNAs, ribosomal components, translation initiation factors, and RNA-binding proteins.
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Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis.
Cristian A. Droppelmann,Brian A. Keller,Danae Campos-Melo,Kathryn Volkening,Michael J. Strong +4 more
TL;DR: RGNEF cytoplasmic inclusions in ALS spinal motor neurons that colocalized with ubiquitin, p62/sequestosome-1, and TAR (trans-active regulatory) DNA-binding protein 43 (TDP-43) are observed, providing further evidence that RNA metabolism pathways are integral to ALS pathology.
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RNA-binding proteins as molecular links between cancer and neurodegeneration.
TL;DR: The evidence for RBPs as being key a molecular linkages between cancer and neurodegeneration is examined.