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Daniela Bonofiglio
Researcher at University of Calabria
Publications - 130
Citations - 4733
Daniela Bonofiglio is an academic researcher from University of Calabria. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 38, co-authored 99 publications receiving 3846 citations.
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Journal ArticleDOI
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.
Adele Vivacqua,Daniela Bonofiglio,Anna Grazia Recchia,Anna Maria Musti,Didier Picard,Sebastiano Andò,Marcello Maggiolini +6 more
TL;DR: A new mode of action of E2 and OHT in endometrial cancer cells is demonstrated, contributing to a better understanding of the molecular mechanisms involved in their uterine agonistic activity.
Journal ArticleDOI
17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.
Adele Vivacqua,Daniela Bonofiglio,Lidia Albanito,Antonio Madeo,Vittoria Rago,Amalia Carpino,Anna Maria Musti,Didier Picard,Sebastiano Andò,Marcello Maggiolini +9 more
TL;DR: The G protein-coupled receptor 30 (GPR30) and the mitogen-activated protein kinase (MAPK) pathway mediate both the up-regulation of c-fos and the growth response to E2, G, and OHT in TC cells studied, which provides new insight into the molecular mechanisms through which estrogens may induce the progression of TC.
Journal Article
Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells.
Marcello Maggiolini,Daniela Bonofiglio,Stefania Marsico,Maria Luisa Panno,Bruno Cenni,Didier Picard,Sebastiano Andò +6 more
TL;DR: The mode of action of phytoestrogens and the balance between being risk or chemopreventive factors for breast cancer may depend on the dietary load.
Journal ArticleDOI
Obesity, Leptin and Breast Cancer: Epidemiological Evidence and Proposed Mechanisms.
Sebastiano Andò,Luca Gelsomino,Salvatore Panza,Cinzia Giordano,Daniela Bonofiglio,Ines Barone,Stefania Catalano +6 more
TL;DR: The current knowledge on the epidemiological link existing between obesity and breast cancer and the molecular mechanisms underlying this connection are summarized and the multifaceted role of the obesity adipokine leptin is discussed.
Journal ArticleDOI
Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells.
Pierluigi Plastina,Daniela Bonofiglio,Donatella Vizza,Alessia Fazio,Daniela Rovito,Cinzia Giordano,Ines Barone,Stefania Catalano,Bartolo Gabriele +8 more
TL;DR: The data provide a rational base for the use of Ziziphus extracts in the treatment of breast cancer in Traditional Chinese Medicine and found that the most effective extracts ZE2 and ZE4 shared a number of triterpenic acids, already known for their anticancer activities.