D
Darrin R. Akins
Researcher at University of Texas Southwestern Medical Center
Publications - 19
Citations - 1665
Darrin R. Akins is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Borrelia burgdorferi & Treponema. The author has an hindex of 17, co-authored 19 publications receiving 1615 citations. Previous affiliations of Darrin R. Akins include University of North Texas.
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Journal ArticleDOI
A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state.
TL;DR: C cultivated B. burgdorferi 297 within dialysis membrane chambers implanted into the peritoneal cavities of rats to induce antigenic changes similar to those which occur during mammalian infection represents a novel system for studying Lyme disease spirochetes in a mammalian host-adapted state.
Journal Article
Treponema pallidum and borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages
Justin D. Radolf,L. L. Arndt,Darrin R. Akins,L. L. Curetty,M. E. Levi,Yuenan Shen,L. S. Davis,Michael V. Norgard +7 more
TL;DR: The potential for spirochetal lipoproteins to function as general macrophage activators was demonstrated by the ability of the synthetic analogues to induce IL-1 beta, IL-6, and IL-12, in addition to TNF, in murine and/or human macrophages.
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Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue.
Darrin R. Akins,Stephen F. Porcella,Taissia G. Popova,Dmitriy V. Shevchenko,Scott I. Baker,Minyue Li,Michael V. Norgard,Justin D. Radolf +7 more
TL;DR: Protein export signals from the low‐passage 297 strain of Borrelia burgdorferi were cloned as fusions with an Escherichia coli alkaline phosphatase (PhoA) reporter lacking a signal sequence to demonstrate that at least one member of the B. burgdoferi lipoprotein family appears to be expressed only during infection.
Journal ArticleDOI
Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B.
Michael V. Norgard,Leslie L. Arndt,Darrin R. Akins,Linda L. Curetty,David Harrich,Justin D. Radolf +5 more
TL;DR: The combined data lend additional support to the proposal that spirochetal lipoproteins and LPS initiate monocyte activation via different cell surface events but that the signaling pathways ultimately converge to produce qualitatively similar cellular responses.
Journal ArticleDOI
Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis.
Kayla E. Hagman,Pekka Lahdenne,Taissia G. Popova,Stephen F. Porcella,Darrin R. Akins,Justin D. Radolf,Michael V. Norgard +6 more
TL;DR: The combined studies implicate DBP as a new candidate for a human Lyme disease vaccine after it was found that mice immunized with recombinant DBP were immune to challenge.