Showing papers by "David A. Waldman published in 1977"

Treatment of chronic childhood asthma with beclomethasone dipropionate aerosol: I. A double-blind crossover trial in nonsteroid-dependent patients.

Abstract: Twenty-two children with chronic asthma requiring daily administration of bronchodilators but not steroids were administered 400 µg of beclomethasone dipropionate aerosol (BDA) or a placebo (vehicle) in a double-blind crossover study The experimental design consisted of four study periods (four weeks each): (1) baseline, (2) BDA or placebo treatment, (3) washout, (4) BDA or placebo treatment Evaluation of effectiveness was assessed by daily symptom and medication scores, Wright Peak Flow (WPF) measurements three times each day, and weekly spirometry Pituitary-adrenal function was evaluated by diurnal measurement of cortisol level, intravenous (IV) metyrapone tests, and IV adrenocorticotropic hormone responses Quantitative throat cultures for Candida were taken monthly Twenty-one of 22 patients correctly identified BDA The mean weekly symptom score was 765 ± 108 (mean ± SE) during placebo compared to 213 ± 53 during BDA therapy (P BDA was shown to be highly effective in controlling asthma and produced no adverse effects