David Cotter

TL;DR: These findings suggest that there is reduced frontal cortical glial cell density and neuronal size in major depressive disorder.

TL;DR: It is confirmed that glial cell loss and neuronal size reductions occur in the deeper cortical layers in MDD, but no support is provided for the hypothesis that an altered spatial distribution of glia about neurons plays a role in the development of these changes.

TL;DR: The possible basis of glial cell loss in schizophrenia and depression is discussed and it is suggested that elevated levels of glucocorticoids, due to illness-related stress or to hyperactivity of the hypothalamic-pituitary-adrenal may down-regulate glial activity and so predispose to, or exacerbate psychiatric illness through enhanced excitotoxicity.

TL;DR: Findings provide support for the view that cytoskeletal and mitochondrial dysfunction are important components of the neuropathology of the major psychiatric disorders.

TL;DR: The results of this study indicate that reduced neuronal somal size and increased neuronal density in cortical layers 5 and 6 of the ACC may be key features of schizophrenia, MDD, and BPD.