D
David E. Johnstone
Researcher at National Institutes of Health
Publications - 3
Citations - 1931
David E. Johnstone is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 3, co-authored 3 publications receiving 1896 citations.
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Journal ArticleDOI
Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD).
Gary S. Francis,Claude R. Benedict,David E. Johnstone,Philip C. Kirlin,John Nicklas,Chang Seng Liang,Spencer H. Kubo,Elizabeth Rudin-Toretsky,Salim Yusuf +8 more
TL;DR: It is concluded that neuroendocrine activation occurs in patients with left ventricular dysfunction and no heart failure, and is further increased as overt heart failure ensues and diuretics are added to therapy.
Journal ArticleDOI
Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range: Results of the cholesterol and recurrent events (CARE) trial
Sandra J. Lewis,Lemuel A. Moyé,Frank M. Sacks,David E. Johnstone,Gerald C. Timmis,Jayne Mitchell,Marian C. Limacher,Sherron Kell,Stephen P. Glasser,Jane Grant,Barry R. Davis,Marc A. Pfeffer,Eugene Braunwald +12 more
TL;DR: The Cholesterol and Recurrent Events (CARE) trial investigated whether reducing average cholesterol levels by using pravastatin in patients who have had myocardial infarction would prevent recurrent cardiac events, and reported that patients who were older than the median age of 59 years had a reduced rate of coronary death, nonfatal myocardIAL infarctions, coronary artery bypass grafting, angioplasty, and stroke.
Journal ArticleDOI
Clinical characteristics of patients in studies of left ventricular dysfunction (SOLVD)
David E. Johnstone,Marian Limacher,Michel Rousseau,Chang Seng Liang,Lars Goran Ekelund,Michael Herman,Douglas R. Stewart,Maureen Guillotte,Gina Bjerken,William H. Gaasch,Peter Held,Joel Verter,Dawn Stewart,Salim Yusuf +13 more
TL;DR: Clinical characteristics of patients in both trials were influenced by the gender and race of enrolled patients, and coronary artery bypass surgery was performed less often in women and non-Caucasians.