Dialkylbiaryl phosphines are a valuable class of ligand for Pd-catalyzed amination reactions and have been applied in a range of contexts. This perspective attempts to aid the reader in the selection of the best choice of reaction conditions and ligand of this class for the most commonly encountered and practically important substrate combinations.

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide

Essential oils for the development of eco-friendly mosquito larvicides: A review

The synthesis of carbocyclic eight-membered rings

Repellency of essential oils of some Kenyan plants against Anopheles gambiae.

Acute, synergistic and antagonistic effects of some aromatic compounds on the Spodoptera littoralis Boisd. (Lep., Noctuidae) larvae

Monoterpenoids (mid-1997 to mid-1999)

3-Oxobutanoic acid reacts with aliphatic aldehydes in the presence of pyridine to give α,β-unsaturated methyl ketones in good yields. Analogous results were obtained with a series of other β-oxo acids. Synthesis of (E)-7-methyloct-4-en-3-one, a major constituent of the marine sponge Plakortis zygompha, has been carried out using this methodology. Aromatic aldehydes are generally less reactive under these conditions but give β-ketols when the phenyl ring bears an electron-withdrawing substituent. Some observations on the mechanism of the reaction between 3-oxobutanoic acid and benzaldehyde are presented.

Knoevenagel reactions with β-oxo acids. Regiospecific enol equivalents for syntheses of α,β-unsaturated ketones and of some β-ketols

Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones.

(Z)-1,4-Dihydroxyalk-2-enes react with dicyclohexylcarbodiimide in the presence of catalytic amounts of copper(I) chloride to give O-alkyl monoisoureas which cyclise to give 2-substituted-2,5-dihydrofurans and dicyclohexylurea when they are treated with trifluoroacetic acid. Alkane-1,4-diols likewise give O-alkyl monoisoureas which cyclise to yield tetrahydrofurans.

Conversion of (Z)-1,4-dihydroxyalk-2-enes into 2,5-dihydrofurans and of alkane-1,4-diols into tetrahydrofurans via acid-catalysed cyclisation of the monoisoureas formed by their copper(I)-mediated reactions with dicyclohexylcarbodiimide

David H. Grayson

Papers

Monoterpenoids (mid-1997 to mid-1999)

Knoevenagel reactions with β-oxo acids. Regiospecific enol equivalents for syntheses of α,β-unsaturated ketones and of some β-ketols

Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones.

Conversion of (Z)-1,4-dihydroxyalk-2-enes into 2,5-dihydrofurans and of alkane-1,4-diols into tetrahydrofurans via acid-catalysed cyclisation of the monoisoureas formed by their copper(I)-mediated reactions with dicyclohexylcarbodiimide

Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine.