Showing papers by "David J. Margolis published in 1992"
TL;DR: These results indicate that a significant elevation in serum creatinine occurs in many patients who receive cyclosporine for psoriasis.
Abstract: Background: Cyclosporine has been used to treat a variety of cutaneous and immune-mediated diseases. Nephrotoxicity is the most common major adverse side effect. Objective: The study was designed to investigate the frequency of alterations in serum creatinine in patients with psoriasis receiving 5 mg/kg/day of cyclosporine. Methods: Sixteen patients with severe refractory psoriasis received cyclosporine, 5 mg/kg/ day, for 12 weeks. Serum creatinine was evaluated with respect to each patient's baseline. Results: Serum creatinine levels remained in the normal range, but 10 of 16 patients had a 30% elevation and 5 of 16 patients had a 50% elevation of serum creatinine compared with the patient's baseline value. Conclusion: These results indicate that a significant elevation in serum creatinine occurs in many patients who receive cyclosporine for psoriasis.
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10 citations
TL;DR: The point of the recent article 1 was to call attention to secondary hyperparathyroidism in patients with disorders of keratinization, and by what mechanism(s) could retinoids be responsible for bone demineralization as well as extraskeletal calcifications?
Abstract: —Dr Margolis raises two important issues: (1) do retinoids cause bone demineralization in humans? (2) by what mechanism(s) could retinoids be responsible for bone demineralization as well as extraskeletal calcifications? We emphasize that the point of our recent article 1 was to call attention to secondary hyperparathyroidism in patients with disorders of keratinization. The role of retinoids in that observation is moot. We could not account for the secondary hyperparathyroidism solely on the basis of retinoid ingestion (see Table 2 in our article); further, we could not be certain of a relationship between retinoid ingestion and the compression fracture found in the index patient. Many authors have noted that hypervitaminosis A is associated with radiographic "lucency" or osteopenia in long bones in humans. 2-5 There is no doubt that retinoids directly cause loss of calcium from bones in experimental animals (see reference in 1). Dr Margolis is correct in noting that
1 citations