Showing papers by "David J. Margolis published in 1993"

Hydroxyurea and lower leg ulcers.

Abstract: We report four cases of cutaneous lower leg ulcers associated with hydroxyurea treatment for myeloproliferative disorders. This association has been reported in one other series of patients who had chronic myelogenous leukemia and were treated with hydroxyurea. A review of the literature and survey of possible pathogenetic mechanisms is presented.

Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing

Abstract: Background: Venous leg ulcers are a common cause of morbidity, but few predictive parameters exist that can be used to follow their progress. Objective: We investigated the use of healing rate as a useful parameter in the treatment of venous ulceration. Methods: Twenty–seven venous ulcers being treated with a standard regimen were evaluated. We calculated the initial (4-week) and overall healing rates using the Gilman method (ΔA/p). Results: The average initial healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.069, 0.087, and −0.005 cm/wk, respectively. Similarly, the average overall healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.062, 0.089, and −0.043 cm/wk, respectively. Conclusion: The initial healing rate (ΔA/p(0–4)) may be an appropriate end point for clinical investigations comparing therapies for the treatment of chronic venous leg ulcers.

Venous leg ulcers: an analysis of underlying venous disease

Abstract: Patients with venous leg ulcers have a readily recognized clinical syndrome of shallow ulcers, oedema, leg pain, venous ankle blush, lipodermatosclerosis, varicose veins, hyperpigmentation, and atrophie blanche, and they are assumed to have venous abnormalities. We examined 43 patients with venous leg ulcers, and compared those with obvious venous abnormalities (defined as historical or clinical evidence of deep venous thrombosis or varicose veins) with those with presumed venous abnormalities (defined as lacking any such evidence), to see if they presented with different clinical features. We found that both groups had similar clinical features, with the exception that lipodermatosclerosis was present more frequently in those patients with obvious venous abnormalities (94 vs. 36%, P < 0.001). Most patients with presumed venous abnormalities had musculoskeletal conditions which might cause calf pump dysfunction (91%). Using air plethysmography, we were unable to confirm that all patients with presumed venous abnormalities did have intrinsic venous abnormalities. We propose that ulcers occurring in this clinical syndrome be designated as calf pump dysfunction ulcers (CPD ulcers), rather than venous ulcers.