D
David M. Gundermann
Researcher at University of Texas Medical Branch
Publications - 29
Citations - 1892
David M. Gundermann is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Skeletal muscle & mTORC1. The author has an hindex of 15, co-authored 27 publications receiving 1652 citations. Previous affiliations of David M. Gundermann include University of Texas at Austin.
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Journal ArticleDOI
Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis
Christopher S. Fry,Micah J. Drummond,Erin L. Glynn,Jared M. Dickinson,David M. Gundermann,Kyle L. Timmerman,Dillon K. Walker,Shaheen Dhanani,Elena Volpi,Blake B. Rasmussen +9 more
TL;DR: It is concluded that aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis, which may contribute to the blunted hypertrophic response seen after resistance-exercise training in older adults.
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Mammalian Target of Rapamycin Complex 1 Activation Is Required for the Stimulation of Human Skeletal Muscle Protein Synthesis by Essential Amino Acids
Jared M. Dickinson,Christopher S. Fry,Micah J. Drummond,David M. Gundermann,Dillon K. Walker,Erin L. Glynn,Kyle L. Timmerman,Shaheen Dhanani,Elena Volpi,Blake B. Rasmussen +9 more
TL;DR: Data support a fundamental role for mTORC1 activation as a key regulator of human muscle protein synthesis in response to increased EAA availability.
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Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults
Micah J. Drummond,Jared M. Dickinson,Christopher S. Fry,Dillon K. Walker,David M. Gundermann,Paul T. Reidy,Kyle L. Timmerman,Melissa M. Markofski,Douglas Paddon-Jones,Blake B. Rasmussen,Elena Volpi +10 more
TL;DR: It is concluded that bed rest in older adults significantly attenuated the EAA-induced increase in MPS with a mechanism involving reduced mTORC1 signaling and amino acid transporter protein content.
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Skeletal Muscle Autophagy and Protein Breakdown Following Resistance Exercise are Similar in Younger and Older Adults
Christopher S. Fry,Micah J. Drummond,Erin L. Glynn,Jared M. Dickinson,David M. Gundermann,Kyle L. Timmerman,Dillon K. Walker,Elena Volpi,Blake B. Rasmussen +8 more
TL;DR: Ageing does not influence skeletal MPB, autophagy, or the ubiquitin proteasome system following an acute bout of RE, and targeting the muscle protein synthesis response to exercise may hold more promise in the prevention of sarcopenia.
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Protein Blend Ingestion Following Resistance Exercise Promotes Human Muscle Protein Synthesis
Paul T. Reidy,Dillon K. Walker,Jared M. Dickinson,David M. Gundermann,Micah J. Drummond,Kyle L. Timmerman,Christopher S. Fry,Michael S. Borack,Mark B. Cope,Ratna Mukherjea,Kristofer Jennings,Elena Volpi,Blake B. Rasmussen +12 more
TL;DR: In this article, a double-blind, randomized, clinical trial was conducted to investigate the effect of protein blend of soy and whey proteins on the fractional synthetic rate (FSR) following resistance exercise.