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David R. Wolstenholme
Researcher at University of Utah
Publications - 66
Citations - 7108
David R. Wolstenholme is an academic researcher from University of Utah. The author has contributed to research in topics: Mitochondrial DNA & Gene. The author has an hindex of 38, co-authored 66 publications receiving 6799 citations. Previous affiliations of David R. Wolstenholme include Kansas State University & Max Planck Society.
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Book ChapterDOI
Animal mitochondrial DNA: structure and evolution.
TL;DR: The extent of size reduction within metazoan mitochondrial-transfer RNA (mt-tRNA) gene sets strongly correlates with the degree to which the more variable secondary structure element-forming regions of mt-rRNA genes are lost.
Journal ArticleDOI
The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code.
TL;DR: Evidence is summarized that supports the hypothesis that A and T nucleotides are favored at all locations in the D. yakuba mtDNA molecule where these nucleotide are compatible with function.
Journal ArticleDOI
The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum
TL;DR: From considerations of amino acid and nucleotide sequence similarities it appears likely that the C. elegans and A. suum ancestral lines diverged close to the time of divergence of the cow and human ancestral lines, about 80 million years ago.
Journal ArticleDOI
Bizarre tRNAs inferred from DNA sequences of mitochondrial genomes of nematode worms.
David R. Wolstenholme,Jane L. Macfarlane,Ronald Okimoto,Douglas O. Clary,Jill A. Wahleithner +4 more
TL;DR: The complete nucleotide sequence of the mitochondrial DNA (mtDNA) molecule of the parasitic nematode worm Ascaris suum has been determined and transfer RNA genes with a similar potential secondary structure are found in mtDNA of the free-living nematodes Caenorhabditis elegans, suggesting that this unusual form of tRNA is used by all nematODE mitochondria.
Journal ArticleDOI
Platyhelminth mitochondrial DNA: evidence for early evolutionary origin of a tRNA(serAGN) that contains a dihydrouridine arm replacement loop, and of serine-specifying AGA and AGG codons.
TL;DR: Findings concerning F. hepatica mtDNA indicate that both a dihydrouridine arm replacement loop-containing tRNAserAGN gene and the use of AGA and AGG codons to specify serine must first have occurred very early in, or before, the evolution of metazoa.