General principles are reviewed for ion mobility spectrometry including new methods for ion separation through field dependent mobilities in strong electric fields with high frequency asymmetric waveform. Additionally, recent advances in the instrumentation for the characterization of ion mobilities in air at ambient pressure are described and critically reviewed. Advances in instrumentation, understanding of principles of measurements by IMS, and the development of hyphenated technologies have resulted in an increase in the number of applications in recent years.

Ion Mobility Spectrometry: Principles and Applications

The general principles and technical implementations of traditional time-of-flight ion mobility spectrometers and analyzers with field-dependent mobilities were reviewed in our last article in this journal. Recent advances in instrumentation and new applications since 2006 are highlighted in this review. In addition to traditional applications as military chemical-agent detectors, ion mobility techniques have become popular for different purposes. Though ion mobility spectrometry was solely used as vapor sensor in the past decades, further developments in ionization techniques (especially electrospray ionization) now permit its routine use for the analysis of liquid samples. The coupling of ion mobility spectrometry with selective sample preparation techniques such as molecular-imprinted polymers, coupling with chromatographic techniques, the use of dopants, and application of selective ionization sources has led to an expanded number of applications in industrial and environmental analysis with ...

Recent Developments in Ion Mobility Spectrometry

An ultra compact ion mobility based analyzer in a multilayered chip assembly employing various features such as a ion flow generator to propel ions through an ion mobility based filter and, thereby, reduce analyzer size, cost, and power requirements

Ultra compact ion mobility based analyzer apparatus, method, and system

The invention includes an ion mobility spectrometer having a liquid filled drift chamber. The chamber has an ionization region partitioned from and an ion separation region by a reversible ion-migration block. An electrical field within the chamber allows ions to migrate toward the electrode collector. Passage of ions from the ionization region is triggered by reversing the block allowing ions to migrate into the ion separation region. The invention includes a method of ion mobility analysis in liquid phase. Ions are mobilized to migrate through a drift liquid and are detected at an end of a drift chamber. The invention also includes a method of generating ions in a sample. A sample containing molecules in a first solvent is introduced into a second solvent through a charged capillary where the electrically charged sample is electro-disperses to ionize the molecules.

Ion Mobility Spectrometry Method and Apparatus

A novel high ion storage/ ion mobility separation mass spectrometer that provides for a high duty cycle of operation is presented herein. In particular, the example embodiments, as disclosed herein, provides for a high ion storage/ ion mobility instrument that beneficially includes a two-dimensional (2D) plurality of adjacently arranged ion confinement channels to provide a high storage bank of a desired mass range of ions. Such ions, via ion mobility transport, are separated into smaller fractions of an overall mass window into desired confinement regions of the disclosed 2D confinement channels and thereafter transferred out in a manner so as to enable the aforementioned novel high-duty cycle of sequential operation.

High duty cycle ion storage/ion mobility separation mass spectrometer

An ion mobility spectrometer is described having an ion filter in the form of at least one ion channel having a plurality of electrodes. A time-varying electric potential applied to the conductive layers allows the filler to selectively admit ion species. The electric potential has a drive and a transverse component, and in preferred embodiments each of the electrodes is involved in generating a component of both the drive and transverse fields. The device may be used without a drift gas flow, Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer.

Ion Mobility Spectrometer

An ion mobility spectrometer is described having an ion filter in the form of multiple parallel ion channels defined by conductive layers (6, 8) separated by non-conductive layers (7, 9). A time-varying electric potential applied to the conductive layers allows the filter to selectively admit ion species. The device may be used without a drift gas flow. Microfabrication techniques are described for producing microscale spectrometers, as are various uses of the spectrometer.

Micromachined field asymmetric ion mobility spectrometer

L'invention concerne un spectrometre de mobilite ionique comprenant un filtre ionique se presentant sous la forme d'au moins un canal ionique comprenant une pluralite d'electrodes. Un potentiel electrique variant dans le temps applique sur les couches conductrices permet au filtre d'admettre de maniere selective des especes ioniques. Le potentiel electrique comprend un pilote et un composant transversal et, dans des modes de realisation preferes, chaque electrode est impliquee dans la generation d'un composant des champs d'entrainement et transversaux. Le dispositif peut etre utilise sans ecoulement de gaz de derive. L'invention concerne egalement des techniques de micro-fabrication permettant de produire des spectrometres a l'echelle microscopique, ainsi que diverses utilisations du spectrometre.

Spectrometre de mobilite ionique

La presente invention se rapporte a un spectrometre de mobilite ionique asymetrique de champ micro-usine, qui comprend un filtre ionique se presentant sous la forme de multiples canaux ioniques paralleles, definis par des couches conductrices (6, 8) separees par des couches non conductrices (7, 9). L'application d'un potentiel electrique variant dans le temps sur les couches conductrices permet au filtre de faire passer selectivement des especes ioniques vers l'electrode collectrice. Le dispositif selon l'invention peut etre utilise sans l'ecoulement d'un gaz de mobilite. L'invention a egalement trait a des techniques de microfabrication permettant de produire des spectrometres de petite echelle, ainsi qu'a diverses utilisations du spectrometre selon l'invention.

David Ruiz Alonso

Papers

Ion Mobility Spectrometer

Micromachined field asymmetric ion mobility spectrometer

Spectrometre de mobilite ionique

Spectromètre de mobilité ionique asymétrique de champ micro-usiné