Primary vaginal melanoma: Thirteen-year disease-free survival after wide local excision and review of recent literature

An analysis of 346 cases of clear cell adenocarcinoma of the vagina and cervix with emphasis on recurrence and survival

Malignant melanoma of the vagina: A case report of progression from preexisting melanosis☆

Vulvovaginal melanoma: report of seven cases and literature review.

Primary vaginal leiomyosarcoma is a rare tumor We report a unique case of a 27-year-old woman with stage I, high-grade primary leiomyosarcoma of the vagina treated with surgical resection and adjuvant radiation therapy She returned within 6 months with an abdominal-pelvic recurrence and lung metastases The patient died of disease 9 months after diagnosis A comprehensive review of primary vaginal leiomyosarcoma was performed and factors affecting survival were analyzed A Medline search of the English-language literature revealed 66 previously reported cases Forty-eight of these had follow-up data Survival probabilities were calculated using the Kaplan-Meier method, and the effects of age, stage, grade, tumor location, and treatment modality were analyzed Stage III and IV data were combined The overall 5-year survival rate was 43% Patients more than 50 years of age had a 5-year survival rate of 26% compared with 51% for those less than 40 years Five-year survival for stage I and II tumors was 55% and 44%, respectively Patients with stage III/IV disease had 25% survival at 18 months No patient treated primarily with chemotherapy or radiation therapy survived beyond 36 months In contrast, patients treated primarily with surgery had a 5-year survival rate of 57% Only stage remained an independent predictor of survival on Cox regression analysis We continue to recommend surgical resection as primary treatment Exenteration may be an option for select patients, but ultimately management should continue on a case-by-case basis

Primary leiomyosarcoma of the vagina. A case report and literature review.

Carcinoma of the vagina may be found in association with carcinoma of the vulva and cervix. Patients with neoplasms in any of these locations should have careful inspection of the entire anogenital tract. As in all malignancies, early diagnosis and prompt, adequate treatment offers the best opportunity for cure.

Davis Pc

Papers

Cancer of the vagina.