Biological activities and distribution of plant saponins.

Saponins, classification and occurrence in the plant kingdom

An ethnobotanical study was conducted from October 2005 to June 2006 to investigate the uses of medicinal plants by people in Zegie Peninsula, northwestern Ethiopia. Information was gathered from 200 people: 70 female and 130 males, using semistructured questionnaire. Of which, six were male local healers. The informants, except the healers, were selected randomly and no appointment was made prior to the visits. Informant consensus factor (ICF) for category of aliments and the fidelity level (FL) of the medicinal plants were determined. Sixty-seven medicinal plants used as a cure for 52 aliments were documented. They are distributed across 42 families and 64 genera. The most frequently utilized plant part was the underground part (root/rhizome/bulb) (42%). The largest number of remedies was used to treat gastrointestinal disorder and parasites infections (22.8%) followed by external injuries and parasites infections (22.1%). The administration routes are oral (51.4%), external (38.6%), nasal (7.9%), and ear (2.1%). The medicinal plants that were presumed to be effective in treating a certain category of disease, such as 'mich' and febrile diseases (0.80) had higher ICF values. This probably indicates a high incidence of these types of diseases in the region, possibly due to the poor socio-economic and sanitary conditions of this people. The medicinal plants that are widely used by the local people or used as a remedy for a specific aliment have higher FL values (Carissa spinarum, Clausena anisata, Acokanthera schimperi, Calpurnia aurea, Ficus thonningii, and Cyphostemma junceum) than those that are less popular or used to treat more than one type of aliments (Plumbago zeylanicum, Dorstenia barnimiana).

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Ethnobotanical study of medicinal plants used by people in Zegie Peninsula, Northwestern Ethiopia

http://www.ethnopharmacologia.org/prelude/pdf/bibio-hg-23-giday.pdf

Medicinal plants of the Meinit ethnic group of Ethiopia: an ethnobotanical study.

Medicinal plants have many traditional claims including the treatment of ailments of infectious origin. In the evaluation of traditional claims, scientific research is important. The objective of the study was to determine the presence of antibacterial activity in the crude extracts of some of the commonly used medicinal plants in Malaysia, Andrographis paniculata, Vitex negundo, Morinda citrifolia, Piper sarmentosum, and Centella asiatica. In this preliminary investigation, the leaves were used and the crude extracts were subjected to screening against five strains of bacteria species, Methicillin Resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli, using standard protocol of Disc Diffusion Method (DDM). The antibacterial activities were assessed by the presence or absence of inhibition zones and MIC values. M. citrifolia, P. sarmentosum and C. asiatica methanol extract and A. paniculata (water extract) have potential antibacterial activities to both gram positive S. aureus and Methicillin Resistant S. aureus (MRSA). None of the five plant extracts tested showed antibacterial activities to gram negative E. coli and K. pneumoniae, except for A. paniculata and P. sarmentosum which showed activity towards P. aeruginosa. A. paniculata being the most potent at MIC of 2 g/disc. This finding forms a basis for further studies on screening of local medicinal plant extracts for antibacteria properties.

In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method.

Screening of some medicinal plants of Ethiopia for their anti-microbial properties and chemical profiles

Medicinal plants and other useful plants of Ethiopia


Background: Traditional medicine is an ancient medical practice that is still widely used in prevention and treatment of various health problems in Ethiopia. 
Objective: To evaluate perceptions and practices of modern and traditional health practitioners about traditional medicine in Shirka District of Arsi Zone, Ethiopia. 
Methods: A cross-sectional study pertaining to the perceptions and practices of modern and traditional health practitioners was carried out in February 1999 in four peasant associations of Shirka District. Two types of questionnaires (with closed and open-ended questions) were prepared to assess the respective practitioners. Fourteen modern practitioners and 80 traditional healers were interviewed. 
Results: Most of the practitioners in both systems had used traditional medicine at least once in their lifetime. The indigenous knowledge surrounding traditional medicine is mainly conveyed verbally and to some extent still employs superstitious beliefs and harmful practices. To substantially reduce the drawbacks and promote its positive elements, both types of practitioners expressed their willingness to collaborate among each other and believe in the need for government support. 
Conclusion: The knowledge surrounding traditional medicine incorporates a number of harmful practices. To make matters worse, this knowledge is mostly conveyed verbally which may result in the inevitable distortion of original information leading to the expansion of more and more harmful practices. Therefore, the need for more effort of recording the knowledge is stressed. Government support and coordinated effort among the various institutions are emphasized for promotion and development of traditional medicine. [Ethiop. J. Health Dev. 2002;16(1):19-29]

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Perceptions and practices of modern and traditional health practitioners about traditional medicine in Shirka district, Arsi zone, Ethiopia

Background : Malaria is a major public health problem in the world in general and developing countries in particular, causing an estimated 1-2 million deaths per year, an annual incidence of 300-500 million clinical cases and more than 2 billion people are at risk of infection from it. But it is also becoming more difficult to treat malaria due to the increasing drug resistance. Therefore, the need for alternative drugs is acute. Objective : The This study aims at investigating the in vivo antiplasmodial activity of extracts of the roots and area parts from traditionally used medicinal plant, named Asparagus africanus (Liliaceae). Methods : A rodent malaria parasite, Plasmodium berghei , which was maintained at the Ethiopian Health and Nutrition Research Institute (EHNRI) laboratory, was inoculated into Swiss albino mice. The mice were infected with 1x107 parasites intraperitoneally. The extracts were administered by an intra gastric tube daily for four days starting from the day of parasite inoculation. The control groups received the same amount of solvent (vehicle) used to suspend each dose of the herbal drug. Chloroquine was used as a standard drug, and was administered through the same route. Results : Extracts from the roots and aerial parts of A.africanus were observed to inhibit Plasmodium berghei parasitaemia in the Swiss albino mice by 46.1% and 40.7% respectively. Conclusion : The study could partly confirm the claim in Ethiopian traditional medicine that the plant has therapeutic values in human malaria. There is, thus, the need to initiate further in-depth investigation by using different experimental models. The Ethiopian Journal of Health Development Vol. 20 (2) 2006: 112-118

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Dawit Abebe

Papers

Screening of some medicinal plants of Ethiopia for their anti-microbial properties and chemical profiles

Medicinal plants and other useful plants of Ethiopia

Perceptions and practices of modern and traditional health practitioners about traditional medicine in Shirka district, Arsi zone, Ethiopia

In vivo anti-malarial activity of hydroalcoholic extracts from Asparagus africanus Lam. in mice infected with Plasmodium berghei

Antipyretic properties of the aqueous and ethanol extracts of the leaves of Ocimum suave and Ocimum lamiifolium in mice