D
Daxiang Lu
Researcher at State Administration of Traditional Chinese Medicine of the People's Republic of China
Publications - 24
Citations - 814
Daxiang Lu is an academic researcher from State Administration of Traditional Chinese Medicine of the People's Republic of China. The author has contributed to research in topics: Apoptosis & Oxidative stress. The author has an hindex of 11, co-authored 22 publications receiving 457 citations.
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Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice
Jiayi Zhao,Wei Bi,Shu Xiao,Xin Lan,Xiaofeng Cheng,Jiawei Zhang,Daxiang Lu,Wei Wei,Yanping Wang,Hongmei Li,Yong-Mei Fu,Lihong Zhu +11 more
TL;DR: The data suggest that LPS induced cognitive impairment and neuroinflammation via microglia activation by activating the NF-kB signaling pathway; furthermore, the time points, doses, methods and outcomes of LPS administration between intraperitoneal and intracerebroventricular injections are compared.
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Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-α and IL-1β release and augmentation of IL-10 production
Wenjuan Cao,Wei Zhang,Jingjing Liu,Yuan Wang,Xuemei Peng,Daxiang Lu,Renbin Qi,Yanping Wang,Huadong Wang +8 more
TL;DR: The results indicate that Pae protects mice against lethal LPS challenge, at least in part, through inhibiting TNF-α and IL-1β production and accelerating IL-10 expression.
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α1 adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-α production via modulating ERK1/2 and NF-κB pathway
Xiaohui Yu,Baoyin Jia,Faqiang Wang,Xiuxiu Lv,Xuemei Peng,Yiyang Wang,Hongmei Li,Yanping Wang,Daxiang Lu,Huadong Wang +9 more
TL;DR: It is indicated that activation of α1‐AR by NE suppresses LPS‐induced cardiomyocyte TNF‐α expression and improves cardiac dysfunction during endotoxaemia via promoting myocardial ERK phosphorylation and suppressing NF‐κB activation.
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Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway.
Cuiqin Huang,Caiyan Wen,Mei Yang,Danhui Gan,Danhui Gan,Chongzhu Fan,An Li,Qin Li,Jiayi Zhao,Lihong Zhu,Daxiang Lu +10 more
TL;DR: It is found that lycopene pretreatment effectively enhanced the cell viability, improved the neuron morphology, increased the GSH/GSSG level, restored the mitochondrial membrane potential (ΔΨm) and decreased reactive oxygen species generation.
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The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert-Butyl Hydroperoxide-Induced Neuron Oxidative Damage
Cuiqin Huang,Danhui Gan,Danhui Gan,Chongzhu Fan,Caiyan Wen,An Li,Qin Li,Jiayi Zhao,Zhen Wang,Lihong Zhu,Daxiang Lu +10 more
TL;DR: Ly-NSC-CM could protect neurons from t-BHP-induced oxidative damage and found an antiapoptotic effect related to inhibited expression of Bax/Bcl-2, cytochrome C, and cleaved caspase-3.