D
Deise M. Borchhardt
Researcher at Universidade Federal de Santa Maria
Publications - 10
Citations - 225
Deise M. Borchhardt is an academic researcher from Universidade Federal de Santa Maria. The author has contributed to research in topics: Trifluoromethyl & Triphosgene. The author has an hindex of 6, co-authored 10 publications receiving 208 citations. Previous affiliations of Deise M. Borchhardt include University of São Paulo.
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Journal ArticleDOI
Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides.
Nilo Zanatta,Sydney Hartz Alves,Helena S. Coelho,Deise M. Borchhardt,Pablo Machado,Kelen M. Flores,Fabio M. da Silva,Tatiana B. Spader,Jânio Morais Santúrio,Helio G. Bonacorso,Marcos A. P. Martins +10 more
TL;DR: Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including yeast, filamentous fungi, bacteria, and alga to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity.
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Biochemical evaluation of a series of synthetic chalcone and hydrazide derivatives as novel inhibitors of cruzain from Trypanosoma cruzi
Deise M. Borchhardt,Alessandra Mascarello,Louise Domeneghini Chiaradia,Ricardo José Nunes,Glaucius Oliva,Rosendo A. Yunes,Adriano D. Andricopulo +6 more
TL;DR: The synthesis and inhibitory effects of a series of thirty-three chalcone and seven hydrazide derivatives against the enzyme cruzain from T. cruzi showed promising in vitro inhibition, which suggest the potential of these compounds as lead candidates for further development.
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Convergent synthesis and cruzain inhibitory activity of novel 2-(N'-benzylidenehydrazino)-4-trifluoromethyl -pyrimidines
Nilo Zanatta,Simone S. Amaral,Josiane M. dos Santos,Debora L. de Mello,Liana da S. Fernandes,Helio G. Bonacorso,Marcos A. P. Martins,Adriano D. Andricopulo,Deise M. Borchhardt +8 more
TL;DR: The molecular docking studies suggest that these inhibitors occupy the S2 pocket without irreversible enzyme inactivation, through hydrophobic interactions, thus, indicating a desirable mode of interaction for the design of novel inhibitors.
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Synthesis of N-substituted 6-trifluoromethyl-1,3-oxazinanes
Nilo Zanatta,Adriana M. C. Squizani,Leonardo Fantinel,Fabiane M. Nachtigall,Deise M. Borchhardt,Helio G. Bonacorso,Marcos A. P. Martins +6 more
TL;DR: In this article, the synthesis of two new series of N-substituted 6-trifluoromethyl-1,3-oxazinanes and 6-tricloylamino-1.1,1, 1.1 trifluoro-but-3-en-2-ones with hydrogen and 10% Pd/C was reported.
Journal ArticleDOI
Synthesis and antimicrobial activity of new (4,4,4-trihalo-3-oxo-but-1-enyl)-carbamic acid ethyl esters, (4,4,4-trihalo-3-hydroxy-butyl)-carbamic acid ethyl esters, and 2-oxo-6-trihalomethyl-[1,3]oxazinane-3-carboxylic acid ethyl esters.
Nilo Zanatta,Deise M. Borchhardt,Sydney Hartz Alves,Helena S. Coelho,Adriana M. C. Squizani,Tiago M. Marchi,Helio G. Bonacorso,Marcos A. P. Martins +7 more
TL;DR: The in vitro antimicrobial activity, of some of the three new series of the title compounds, was assessed against a panel of microorganisms including yeast like fungi, bacteria, and algae, and their minimal inhibitory concentration and minimal fungicidal, bactericidal, and algacidal concentrations were determined.