The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

Aldose reductase inhibitors and uses thereof

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.

Aldose reductase inhibitors and methods of use thereof

PROBLEM TO BE SOLVED: To provide novel compounds and pharmaceutical compositions thereof, and methods based on the compounds and compositions, for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders such as cancer, the treatment of tissue damage such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders such as complications arising from diabetes, where the other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the likeSOLUTION: In one aspect, the invention relates to a compound of formula (I) described in the specificationSELECTED DRAWING: None

Aldose reductase inhibitor and method for use thereof

PROBLEM TO BE SOLVED: To provide a new effective and safe medicine for treating a diabetic composition. SOLUTION: The pharmaceutical composition includes a new substituted indole alkanol acid (represented by the general formula I) interacting with an aldose reductase and suppressing the aldose reactase. (Wherein, A is a 1-4C alkylene substituted with a 1-2C alkyl or a mono- or di-substituted with a halogen; z is a bond; R1 is H, a 1-6C alkyl or a halogen; R2 , R3 , R4 and R5 are each independently H, a halogen, nitro, a 1-6C alkyl, (substituted) benzyl or the like; R6 is H or a 1-6C alkyl).

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Substituted indole alkanol acid

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Substituted indole alkanol acid

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