D
Derek M. McKay
Researcher at McMaster University
Publications - 120
Citations - 6324
Derek M. McKay is an academic researcher from McMaster University. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 43, co-authored 101 publications receiving 6016 citations. Previous affiliations of Derek M. McKay include University of Calgary.
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Journal ArticleDOI
Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress
Mehri Zareie,Kathene C. Johnson-Henry,Jennifer Jury,P-C Yang,B-Y Ngan,Derek M. McKay,Johan D. Söderholm,Mary H. Perdue,Philip M. Sherman +8 more
TL;DR: Findings indicate that probiotics can prevent chronic stress induced intestinal abnormalities and, thereby, exert beneficial effects in the intestinal tract.
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Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse
TL;DR: GLP-2 enhances intestinal epithelial barrier function by affecting both paracellular and transcellular pathways and thus may be of therapeutic value in a number of gastrointestinal conditions.
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Corticotropin releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro
Conny Wallon,Ping-Chang Yang,Åsa V. Keita,Ann-Charlott Ericson,Derek M. McKay,Philip M. Sherman,Mary H. Perdue,Johan D. Söderholm +7 more
TL;DR: The results suggest that CRH mediates transcellular uptake of HRP in human colonic mucosa via CRH receptor subtypes R1 and R2 on subepithelial mast cells and may have implications for stress-related intestinal disorders.
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Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine.
TL;DR: It is concluded that acute stressors have profound effects on intestinal epithelial physiology, stimulating ion secretion and reducing barrier function.
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Transforming Growth Factor-β Regulation of Epithelial Tight Junction Proteins Enhances Barrier Function and Blocks Enterohemorrhagic Escherichia coli O157:H7-Induced Increased Permeability
TL;DR: Insight is provided into EHEC pathogenesis by illustrating the mechanisms underlying TGF-beta-induced epithelial barrier enhancement and identifying T GF-beta as an agent capable of blocking EH EC-induced increases in epithelial permeability via maintenance of claudin-2, occludin, and zonula occlUDens-1 levels.