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Diane Gong
Researcher at University of California, San Francisco
Publications - 28
Citations - 1357
Diane Gong is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Anesthetic & Isoflurane. The author has an hindex of 20, co-authored 28 publications receiving 1320 citations. Previous affiliations of Diane Gong include University of Texas at Austin.
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Journal ArticleDOI
Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers.
Edmond I. Eger,Donald D. Koblin,Terri Bowland,Pompiliu Ionescu,Michael J. Laster,Zexu Fang,Diane Gong,James M. Sonner,Richard B. Weiskopf +8 more
TL;DR: Sevoflurane was associated with transient injury to: 1) the glomerulus, as revealed by postanesthetic albuminuria; 2) the proximal tubule, as shown by post-anesthetic glucosuria and increased urinary alpha-GST; and 3) the distal tubules, as Revealed by post anesthetic increased urinary pi-G ST.
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Naturally occurring variability in anesthetic potency among inbred mouse strains.
TL;DR: The results suggest that multiple genes underlie the observed variability in anesthetic potency, and phenotypic differences may be exploited to help determine the genetic basis of anesthetic-induced immobility.
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Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers.
Edmond I. Eger,Diane Gong,Donald D. Koblin,Terri Bowland,Pompiliu Ionescu,Michael J. Laster,Richard B. Weiskopf +6 more
TL;DR: Human and rat kidneys are injured by a reactive compound (Compound A) produced by degradation of the clinical inhaled anesthetic, sevoflurane, with a threshold between 80 and 168 ppm/h of exposure to Compound A.
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Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats : Helium and neon as nonimmobilizers (nonanesthetics)
Donald D. Koblin,Zexu Fang,Edmond I. Eger,Michael J. Laster,Diane Gong,Pompiliu Ionescu,Michael J. Halsey,James R. Trudell +7 more
TL;DR: It has been thought that the high pressures of helium and neon that might be needed to produce anesthesia antagonize their anesthetic properties, but this work proposes an alternative explanation: like other compounds with a low affinity to water, helium and Neon are intrinsically without anesthetic effect.
Journal ArticleDOI
Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds.
TL;DR: Absence of the neural form of protein kinase C increases minimum alveolar anesthetic concentration for isoflurane, indicating that protein phosphorylation by the gamma-isoform of protein Kinase C (PKCgamma) can influence the potency of this anesthetic.