Recently, due to the COVID-19 pandemic and the related social distancing measures, in-person activities have been significantly reduced to limit the spread of the virus, especially in healthcare settings. This has led to loneliness and social isolation for our most vulnerable populations. Socially assistive robots can play a crucial role in minimizing these negative affects. Namely, socially assistive robots can provide assistance with activities of daily living, and through cognitive and physical stimulation. The ongoing pandemic has also accelerated the exploration of remote presence ranging from workplaces to home and healthcare environments. Human-robot interaction (HRI) researchers have also explored the use of remote HRI to provide cognitive assistance in healthcare settings. Existing in-person and remote comparison studies have investigated the feasibility of these types of HRI on individual scenarios and tasks. However, no consensus on the specific differences between in-person HRI and remote HRI has been determined. Furthermore, to date, the exact outcomes for in-person HRI versus remote HRI both with a physical socially assistive robot have not been extensively compared and their influence on physical embodiment in remote conditions has not been addressed. In this paper, we investigate and compare in-person HRI versus remote HRI for robots that assist people with activities of daily living and cognitive interventions. We present the first comprehensive investigation and meta-analysis of these two types of robotic presence to determine how they influence HRI outcomes and impact user tasks. In particular, we address research questions regarding experience, perceptions and attitudes, and the efficacy of both humanoid and non-humanoid socially assistive robots with different populations and interaction modes. The use of remote HRI to provide assistance with daily activities and interventions is a promising emerging field for healthcare applications. 

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A Meta-Analysis on Remote HRI and In-Person HRI: What Is a Socially Assistive Robot to Do?

A high dose of amoxicillin is recommended as the first-line therapy for acute bacterial rhinosinusitis (ABR). However, oral administration of amoxicillin is connected to many adverse reactions coupled with moderate bioavailability (~60%). Therefore, this study aimed to develop a topical nasal preparation of amoxicillin, employing a thermoresponsive nanogel system to increase nasal residence time and prolong drug release. Rheological investigations revealed that formulations containing 21–23% w/w Poloxamer 407 (P407) were in accordance with the requirement of nasal administration (gelling temperature ~35 °C). The average hydrodynamic diameter (<200 nm), pH (6.7–6.9), and hypertonic osmolality (611–663 mOsmol/L) of the in situ gelling nasal nanogel appeared as suitable characteristics for local rhinosinusitis treatment. Moreover, taking into account the mucoadhesive strength and drug release studies, the 21% w/w P407 could be considered as an optimized concentration for effective nasal delivery. Antibacterial activity studies showed that the ability of amoxicillin-loaded in situ gelling nasal nanogel to inhibit bacterial growth (five common ABR pathogens) preserved its effectiveness in comparison to 1 mg/mL amoxicillin aqueous solution as a positive control. Altogether, the developed amoxicillin-loaded in situ gelling thermoresponsive nasal nanogel can be a potential candidate for local antibiotic therapy in the nasal cavity.

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Development of Thermoresponsive-Gel-Matrix-Embedded Amoxicillin Trihydrate-Loaded Bovine Serum Albumin Nanoparticles for Local Intranasal Therapy

Carboxymethylcellulose (CMC)/glutaraldehyde (GA)-modified Ti3C2Tx membrane and its efficient ion sieving performance

Owing to their complicated pathophysiology, the treatment of skin diseases necessitates a complex approach. Conventional treatment using topical corticosteroids often results in low effectiveness and the incidence of local or even systemic side effects. Nanoformulation of potent anti-inflammatory drugs has been selected as an optimal strategy for enhanced topical delivery of corticosteroids. In order to assess the efficiency of various nanoformulations, we formulated hydrocortisone (HC) and hydrocortisone-17-butyrate (HCB) into three different systems: lipid nanocapsules (LNC), polymeric nanoparticles (PNP), and ethosomes (ETZ). The systems were characterized using dynamic light scattering for their particle size and uniformity and the morphology of nanoparticles was observed by transmission electron microscopy. The nanosystems were tested using ex vivo full thickness porcine and human skin for the delivery of HC and HCB. The skin penetration was observed by confocal microscopy of fluorescently labelled nanosystems. ETZ were proposed as the most effective delivery system for both transdermal and dermal drug targeting but were also found to have a profound effect on the skin barrier with limited restoration. LNC and PNP were found to have significant effects in the dermal delivery of the actives with only minimal transdermal penetration, especially in case of HCB administration.

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The Contest of Nanoparticles: Searching for the Most Effective Topical Delivery of Corticosteroids

Effect of zeta potential of innovative lipid nanocapsules on triamcinolone transdermal delivery

Education systems are currently in a state of uncertainty in the face of the changes and complexities that have accompanied SARS-CoV2, leading to new directions in educational models and curricular reforms. Video-based Intervention (VBIs) is a form of observational learning based on social learning theory. Thus, this study aims to make use of a humanoid robot called NAO, which has been used in educational interventions for children with autism spectrum disorder. Integrating it in video-based interventions. This study aims to characterize, in an everyday context, the mediating role of the NAO robot presented in group videoconferences to stimulate video-based on observational learning for children with cognitive and social communication deficits. The children in the study demonstrated a minimal ability to understand simple instructions. This qualitative study was applied to three children with autism spectrum disorder (ASD), level III special education students at Center for Special Basic Education (CEBE) in the city of Arequipa, Peru. Likewise, an instrument was designed for assessment of the VBIs by a group of psychologists. The results showed that the presence of the NAO robot in the VBIs successfully stimulated their interaction capabilities.

Diego Antonio Urdanivia Alarcon

Papers

Effect of zeta potential of innovative lipid nanocapsules on triamcinolone transdermal delivery

Exploring the Effect of Robot-Based Video Interventions for Children with Autism Spectrum Disorder as an Alternative to Remote Education