Dillon Cleary

TL;DR: The results suggest that the induction of host immune responses by pretreatment with SB 9200 followed by ETV resulted in antiviral efficacy that was superior to that obtained using the strategy of viral reduction with ETV followed by immunomodulation.

TL;DR: A focused library of oxazolidinone analogues is synthesized and evaluated, finding polar and/or charge-carrying modifications that, when combined in hybrid C-ring analogues, appear to largely overcome the efflux and/ or permeability barriers, resulting in improved Gram-negative activity.

TL;DR: In this article, the authors describe compounds and compositions for the induction of expression of a pattern recognition receptor (e.g., STING) and methods of use thereof, and propose a method of using STING for pattern recognition.

TL;DR: The results demonstrated that distributing the charge-carrying moieties across two rings was also beneficial for avoidance of the outer membrane barriers and provide the medicinal chemist with a framework and strategy for overcoming the OM barriers in GNB in antibacterial drug discovery efforts.

TL;DR: In vivo efficacy and safety studies of SB 11285 are reported on, finding activation of innate and adaptive immunity via Stimulator of Interferon Genes (STING) signaling is a potentially transformative immuno-therapeutic strategy in cancer.