Bio-based succinate is receiving increasing attention as a potential intermediary feedstock for replacing a large petrochemical-based bulk chemical market. The prospective economical and environmental benefits of a bio-based succinate industry have motivated research and development of succinate-producing organisms. Bio-based succinate is still faced with the challenge of becoming cost competitive against petrochemical-based alternatives. High succinate concentrations must be produced at high rates, with little or no by-products to most efficiently use substrates and to simplify purification procedures. Herein are described the current prospects for a bio-based succinate industry, with emphasis on specific bacteria that show the greatest promise for industrial succinate production. The succinate-producing characteristics and the metabolic pathway used by each bacterial species are described, and the advantages and disadvantages of each bacterial system are discussed.

Prospects for a bio-based succinate industry

Recovery of carboxylic acids produced by fermentation

https://deepblue.lib.umich.edu/bitstream/handle/2027.42/34497/1_ftp.pdf?sequence=1

Significance of controlling crystallization mechanisms and kinetics in pharmaceutical systems

http://web.mit.edu/braatzgroup/87_First-principles_and_direct_design_approaches_for_the_control_of_pharmaceutical_crystallization.pdf

First-principles and direct design approaches for the control of pharmaceutical crystallization

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

ATR FTIR spectroscopy for in situ measurement of supersaturation

An investigation of the applicability of attenuated total reflection infrared spectroscopy for measurement of solubility and supersaturation of aqueous citric acid solutions

A highly efficient process for the production and recovery of pure succinic acid from a succinate salt that involves minimal use of additional reagents, and produces virtually no waste by-products, and permits internal recycle of the base and acid values, is provided. The method involves the formation of diammonium succinate, either by using an ammonium ion based material to maintain neutral 8 pH in the fermenter or by substituting the ammonium cation for the cation of the succinate salt created in the fermenter. The diammonium succinate can then be reacted with a sulfate ion, such as by combining the diammonium succinate with ammonium bisulfate and/or sulfuric acid at sufficiently low pH to yield succinic acid and ammonium sulfate. The ammonium sulfate is advantageously cracked thermally into ammonia and ammonium bisulfate. The succinic acid can be purified with a methanol dissolution step. Various filtration, reflux and reutilization steps can also be employed.

Succinic acid production and purification

A variety of porous optically transparent titanium carboxylate films that can be supported on silicate glass substrates have been developed. These films were made by spin casting polymeric solution ...

Application of controlled hydrolysis of titanium(IV) isopropoxide to produce sol-gel-derived thin films

The feasibility of using sol-gel derived titanium carboxylate thin film, which a can be supported on glass, for the fabrication of optical test strips was investigated using a model probe/ananlyte combination. The porous films, being optically transparent and having the capability to host probe molecules, proveded an excellent system to investigate the possibility of making optical test strips. A comorimetric reagent, an iron-(III) propohyring was chosen as the rpobe molecule to detect free cyanid ion concentrations in aqueous solutions

Dilum Dunuwila

Papers

ATR FTIR spectroscopy for in situ measurement of supersaturation

An investigation of the applicability of attenuated total reflection infrared spectroscopy for measurement of solubility and supersaturation of aqueous citric acid solutions

Succinic acid production and purification

Application of controlled hydrolysis of titanium(IV) isopropoxide to produce sol-gel-derived thin films

Sol-gel derived titanium carboxylate thin films for optical detection of analytes