https://journal.chestnet.org/article/S0012-3692(12)60129-9/pdf

Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Progress in public health and community-based interventions has been hampered by the lack of a comprehensive evaluation framework appropriate to such programs. Multilevel interventions that incorporate policy, environmental, and individual components should be evaluated with measurements suited to their settings, goals, and purpose. In this commentary, the authors propose a model (termed the RE-AIM model) for evaluating public health interventions that assesses 5 dimensions: reach, efficacy, adoption, implementation, and maintenance. These dimensions occur at multiple levels (e.g., individual, clinic or organization, community) and interact to determine the public health or population-based impact of a program or policy. The authors discuss issues in evaluating each of these dimensions and combining them to determine overall public health impact. Failure to adequately evaluate programs on all 5 dimensions can lead to a waste of resources, discontinuities between stages of research, and failure to improve ...

Evaluating the public health impact of health promotion interventions: the RE-AIM framework.

https://www.healthcare.uiowa.edu/familymedicine/fpinfo/Docs/Chest%20Rx%20VTE%20Feb%202016.pdf

Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report

A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey.

This review found that 4 benchmark institutions have done most of the published research on the effects of the electronic health record on medical care. The research shows that electronic health re...

Systematic Review: Impact of Health Information Technology on Quality, Efficiency, and Costs of Medical Care

Objective: To define risk factors for complications that occur during warfarin therapy. Design: Retrospective cohort study. Setting: Five anticoagulation clinics. Patients: Nine hundred twenty-eigh...

Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study

Objective: To determine whether increasing age is associated with an increased risk for bleeding during warfarin treatment. Design: Combined retrospective and prospective cohort studies. Setting: 6...

The Risk for and Severity of Bleeding Complications in Elderly Patients Treated with Warfarin

A number of treatments are widely prescribed for chronic back pain, but few have been rigorously evaluated. We examined the effectiveness of transcutaneous electrical nerve stimulation (TENS), a program of stretching exercises, or a combination of both for low back pain. Patients with chronic low back pain (median duration, 4.1 years) were randomly assigned to receive daily treatment with TENS (n = 36), sham TENS (n = 36), TENS plus a program of exercises (n = 37), or sham TENS plus exercises (n = 36). After one month no clinically or statistically significant treatment effect of TENS was found on any of 11 indicators of outcome measuring pain, function, and back flexion; there was no interactive effect of TENS with exercise. Overall improvement in pain indicators was 47 percent with TENS and 42 percent with sham TENS (P not significant). The 95 percent confidence intervals for group differences excluded a major clinical benefit of TENS for most outcomes. By contrast, after one month patients in ...

https://www.nejm.org/doi/pdf/10.1056/NEJM199006073222303

A Controlled Trial of Transcutaneous Electrical Nerve Stimulation (TENS) and Exercise for Chronic Low Back Pain

Infant mental and motor development at 8 mo of age is significantly related to maternal alcohol use during early pregnancy. Data on 462 infants were analyzed with multiple regression techniques, adjusting for effects of nicotine, caffeine, gestational age, parity, and maternal education. Other possible intervening variables were evaluated and not found to explain the results. This study presents further evidence that maternal alcohol use during pregnancy at levels of about four drinks per day and above has an adverse effect on offspring, even in a sample that is basically low risk.

Effects of Maternal Alcohol, Nicotine, and Caffeine Use During Pregnancy on Infant Mental and Motor Development at Eight Months

This report is one phase of a longitudinal prospective study on the behavioral teratology of alcohol The present study evaluated the effect of early prenatal alcohol exposure (assessed during pregnancy) on reaction time, attention and distraction in 475 young school-age children who took a computerized CPT vigilance task Multiple regression analyses were adjusted for a variety of co-variates including other exposures, postnatal conditions and demographics Prenatal alcohol exposure was most significantly related to CPT errors of commission, reaction time, and the vigilance errors summary score Error scores on the vigilance task were also significantly correlated with independent behavior ratings of endurance, persistence, organization, distractibility and impulsivity This study supports and extends earlier reports of alcohol-related attentional deficits observable in the neonatal period and in the preschool years

Donald C. Martin

Papers

Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study

The Risk for and Severity of Bleeding Complications in Elderly Patients Treated with Warfarin

A Controlled Trial of Transcutaneous Electrical Nerve Stimulation (TENS) and Exercise for Chronic Low Back Pain

Effects of Maternal Alcohol, Nicotine, and Caffeine Use During Pregnancy on Infant Mental and Motor Development at Eight Months

Attention, distraction and reaction time at age 7 years and prenatal alcohol exposure.