We have studied 26 patients presenting with a symmetrical papular or papulovesicular acrolocated eruption of more than 10 days duration. Mean age at onset was 2 years (range 10 months to 5.75 years). Lymphadenopathy was noted in eight cases, and hepatomegaly in one case. In 12 cases, histopathology and direct immunofluorescence were non-contributory. Cytolytic hepatitis occurred in one case and was associated with HBs antigenemia. A history of recent immunization was given in two cases. There was serological evidence of recent Epstein-Barr virus infection in seven out of 13 cases tested. Coxsackie B viruses were isolated from three patients, and cytomegalovirus was probably associated with the syndrome in one case. We conclude that the Gianotti-Crosti syndrome is not rare in France, and that non-hepatitis B virus (HBV)-associated cases are more frequent than the classical HBV-associated papular acrodermatitis of childhood.

Gianotti-Crosti syndrome: a study of 26 cases

Leukonychia. Review and classification.

The Nail in Systemic Diseases

• A 32-year-old woman afflicted with a severe, chronic Epstein-Barr virus (CEBV) infection of 12 months' duration developed an unusual, granuloma annulare-like eruption The cutaneous disorder, which paralleled the clinical course of her disease, was characterized by slightly raised, erythematous, annular lesions predominantly involving the face and arms, with sporadic involvement elsewhere Histopathologic examination of biopsy material obtained from affected skin disclosed a granulomatous dermatitis The patient's symptoms and cutaneous eruption resolved after systemic corticosteroid therapy This eruption may represent a distinct cutaneous component of CEBV infection with clinically granuloma annulare-like features or the mere serendipitous association of CEBV infection and an unusual granulomatous dermatitis Because of the unusual clinical appearance of the eruption and its clear correlation with disease activity, we speculate that it likely represents a distinct cutaneous condition, heretofore unreported, caused by CEBV infection (Arch Dermatol1988;124:250-255)

https://jamanetwork.com/HttpHandlers/ArticlePdfHandler.ashx?journal=derm&articleId=549100&pdfFileName=archderm_124_2_020.pdf

Granuloma annulare-like eruption due to chronic Epstein-Barr virus infection.

Fungal (Onychomycosis) and Other Infections Involving the Nail Apparatus

/pdf/leukonychia-partialis-in-kawasaki-disease-1q79qm81l1.pdf

Leukonychia partialis in Kawasaki disease

A case of papular acrodermatitis (PAC) associated with Epstein-Barr virus in fection occurred in a 9-month-old child. Current knowledge of the possible role of various viral antigens in PAC is discussed.

Papular Acrodermatitis with Epstein-Barr Virus Infection

Yersinia enterocolitica septicemia in an infant presenting as fever of unknown origin.

Congenital syphilis (CS) continues to occur despite widespread serologic testing of pregnant women.' The incidence of CS generally reflects the prevalence of untreated primary and secondary syphilis in women of childbearing age? Reported cases of CS in the United States increased from 115 to 268 during the period 1978-1985: Metropolitan New York and three states-Texas, California, and Florida-accounted for 80% of the reported cases of CS in 1985. Mascola et al., after a retrospective review of 50 cases under 1 year of age, identified risk factors for developing CS.' A prospective study was undertaken in a section of New York City to determine factors that may have resulted in failure of prevention of CS in the first week of life.

Donald S. Gromisch

Papers

Leukonychia partialis in Kawasaki disease

Papular Acrodermatitis with Epstein-Barr Virus Infection

Yersinia enterocolitica septicemia in an infant presenting as fever of unknown origin.

Congenital Syphilis in an Urban Population