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Douglas A. Hardesty
Researcher at Ohio State University
Publications - 75
Citations - 1049
Douglas A. Hardesty is an academic researcher from Ohio State University. The author has contributed to research in topics: Medicine & Radiation therapy. The author has an hindex of 12, co-authored 55 publications receiving 785 citations. Previous affiliations of Douglas A. Hardesty include University of Pennsylvania & Children's Hospital of Philadelphia.
Papers
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Journal ArticleDOI
The value of glioma extent of resection in the modern neurosurgical era
Douglas A. Hardesty,Nader Sanai +1 more
TL;DR: Despite limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade newly diagnosed gliomas.
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The impact of adjuvant stereotactic radiosurgery on atypical meningioma recurrence following aggressive microsurgical resection.
Douglas A. Hardesty,Andrew B. Wolf,David Brachman,Heyoung McBride,Emad Youssef,Peter Nakaji,Randall W. Porter,Kris A. Smith,Robert F. Spetzler,Nader Sanai +9 more
TL;DR: Atypical meningiomas are increasingly irradiated, even after complete or near-complete microsurgical resection, and this analysis of the largest patient series to date suggests that close observation remains reasonable in the setting of aggressive micros surgical resection.
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Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB
David Maag,Micah J. Maxwell,Douglas A. Hardesty,Katie Boucher,Namrata Choudhari,Adam G. Hanno,Jenny F. Ma,Adele S. Snowman,Joseph W. Pietropaoli,Risheng Xu,Phillip B. Storm,Adolfo Saiardi,Solomon H. Snyder,Adam C. Resnick +13 more
TL;DR: Inositol polyphosphate multikinase physiologically generates PIP3 as well as water soluble inositol phosphates and appears to act as a molecular switch, inhibiting or stimulating Akt via its inositl phosphate kinase or PI3-kinase activities, respectively.
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Safety, efficacy, and cost of intraoperative indocyanine green angiography compared to intraoperative catheter angiography in cerebral aneurysm surgery
TL;DR: The replacement of routine intraoper DSA with ICG videoangiography and selective intraoperative DSA in cerebrovascular aneurysm surgery is safe and effective.
Journal ArticleDOI
Evaluation of surgical freedom for microscopic and endoscopic transsphenoidal approaches to the sella.
Ali M. Elhadi,Douglas A. Hardesty,Hasan A. Zaidi,M. Yashar S. Kalani,Peter Nakaji,William L. White,Mark C. Preul,Andrew S. Little +7 more
TL;DR: Comparing the surgical freedom of 4 transsphenoidal approaches to the sella turcica to aid in surgical approach selection provides objective baseline values for the quantification and evaluation of future refinements in surgical technique or instrumentation.