D
Douglas Brown
Researcher at Tufts University
Publications - 8
Citations - 619
Douglas Brown is an academic researcher from Tufts University. The author has contributed to research in topics: Mutant & Corpus albicans. The author has an hindex of 8, co-authored 8 publications receiving 604 citations. Previous affiliations of Douglas Brown include Bishop's University.
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Journal ArticleDOI
Filamentous growth of Candida albicans in response to physical environmental cues and its regulation by the unique CZF1 gene.
TL;DR: The CZF1 gene, encoding a putative transcription factor, was shown to be involved in the regulation of hyphal growth under certain conditions, including embedded conditions, and growth of cells embedded within a matrix promoted the formation of hyphae.
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An acetohydroxy acid synthase mutant reveals a single site involved in multiple herbicide resistance
Jiro Hattori,Douglas Brown,George Mourad,Hélène Labbé,Thérèse Ouellet,Glen Sunohara,Robert G. Rutledge,John King,Brian Miki +8 more
TL;DR: A mutant allele of AHAS3 responsible for sulfonylurea resistance in a Brassica napus cell line was isolated, revealing a single site essential for the binding of all the herbicide classes.
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Multiple resistance to sulfonylureas and imidazolinones conferred by an acetohydroxyacid synthase gene with separate mutations for selective resistance.
TL;DR: It is confirmed that the single base-pair change found near the 3′ end of the coding region of this gene is responsible for imidazolinone resistance, illustrating that a multiple-resistance phenotype can be achieved in an AHAS gene through combinations of separate mutations.
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Stable transformation and regulated expression of an inducible reporter construct inCandida albicans using restriction enzyme-mediated integration
TL;DR: All transformants examined were inducible forURA3 expression, which was determined by growth analysis and by measuring the level ofURA3 gene product activity, and the Ura+ phenotype of the transformants was stable during growth under nonselective conditions.