D
Douglas R. Smith
Researcher at Yale University
Publications - 49
Citations - 29279
Douglas R. Smith is an academic researcher from Yale University. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 32, co-authored 49 publications receiving 27783 citations. Previous affiliations of Douglas R. Smith include University of Pisa & Applied Biosystems.
Papers
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Cannabis microbiome sequencing reveals several mycotoxic fungi native to dispensary grade cannabis flowers
Kevin McKernan,Jessica Spangler,Lei Zhang,Vasisht Tadigotla,Yvonne Helbert,Ted R. Foss,Douglas R. Smith +6 more
TL;DR: The first next generation sequencing survey of the microbial communities found in dispensary based Cannabis flowers is described and the limitations in the culture based regulations that are being superimposed from the food industry are demonstrated.
Posted ContentDOI
Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans
TL;DR: The severe phenotypes associated with rare DAGLA variants underscore the critical role of rapid 2-AG synthesis and the endocannabinoid system in regulating neurological function and development.
Book ChapterDOI
Copy number amplification of yeast artificial chromosomes.
TL;DR: This chapter discusses the system that permits copy number amplification of YACs by introducing certain cis-acting elements into the cloning vector, pCGS966.
Patent
Directed assembly of amplicons to enhance read pairing signature with massively parallel short read sequencers
TL;DR: The present teachings relate to improved methods, kits, and compositions for making nucleic acid libraries and sequencing nucleic acids as mentioned in this paper, in which directionally defined concatamers are generated, facilitating sequencing efforts.
Posted ContentDOI
Targeted gene sequencing in 6994 individuals with neurodevelopmental disorder with epilepsy
Henrike O. Heyne,Mykyta Artomov,Mykyta Artomov,Florian Battke,Claudia Bianchini,Douglas R. Smith,Nora Liebmann,Vasisht Tadigotla,Christine M. Stanley,Dennis Lal,Heidi L. Rehm,Holger Lerche,Mark J. Daly,Mark J. Daly,Ingo Helbig,Saskia Biskup,Yvonne G. Weber,Johannes R. Lemke +17 more
TL;DR: It is shown that improvement of panel design increased diagnostic yield over time, but panels still display genes with low or no diagnostic yield.