Natural history of pulmonary embolism

The natural history of pulmonary embolism.

The release of prostaglandins from lung and other tissues

Some of Gaddum's first publications were on the development of specific and sensitive methods for biological assay, and he maintained a deep interest in this subject for the rest of his life (see Feldberg, 1967). One of the methods which he developed was that of superfusion, first described by Finkleman (1930). In this technique the bathing fluid runs over the external surface of the tissue, and Gaddum (1953) called it \" superfusion \" by analogy with \"perfusion,\" in which the fluid runs through the tissue.

The release and fate of vaso‐active hormones in the circulation

Identification and Characterization of CD39/Vascular ATP Diphosphohydrolase

PLATELET FACTOR 4 (PF4) is a low molecular weight, heat stable protein which neutralizes heparin1,2. Recent reports indicate PF4 is released from human platelets during aggregation by adenosine diphosphate (ADP), adrenaline, thrombin and collagen3,4. It is known that human platelet aggregation in plasma containing citrate proceeds in two phases in response to adrenaline, ADP and thrombin5–8. Reversible platelet aggregation seems to be chiefly the result of changes in the platelet membrane induced by external stimuli. The second phase is accompanied by the selective release of various platelet contents, including adenine nucleotides, 5-hydroxytryptamine and certain lysosomal enzymes9. We have examined the release of PF4 in human platelet-rich plasma with particular reference to the two phases of platelet aggregation. We also compared release of PF4 with ADP release.

Platelet factor 4 and adenosine diphosphate release during human platelet aggregation.

HEMORRHAGIC disorders are common in patients with Laennec's cirrhosis of the liver, and constitute one of the main causes of death in this condition.1 However, the nature of the hemostatic defect in cirrhosis is complex, and thrombocytopenia,2 low procoagulant levels,3 abnormal plasminogen-plasmin system activity4 and defective fibrin polymerization5 have all been implicated. Current concepts of hemostasis emphasize the central role of platelets in the formation of a hemostatic plug.6 Interference with normal platelet function, therefore, is particularly apt to endanger hemostasis. Proteolytic degradation products of fibrinogen, produced as a result of excessive fibrinolysis, have been demonstrated in the blood of . . .

Platelet Aggregation in Patients with Laennec's Cirrhosis of the Liver

In 19 dogs, the release of autologous venous thrombi to the lungs resulted in bronchoconstriction, with a rapid rise in the total lung resistance and a fall in the lung compliance. The respiratory ...

Mechanism of bronchoconstriction produced by thromboemboli in dogs.

In a group of seven patients with pulmonary embolism, evidence of bronchoconstriction was found Heparin appeared to relieve partially the observed airway obstruction A possible common mechanism for the initiation of intravascular coagulation and the production of bronchoconstriction was considered When other causes can be eliminated, the detection of bronchoconstriction may serve as a useful index for the early recognition of pulmonary emboli

Duncan P. Thomas

Papers

Platelet factor 4 and adenosine diphosphate release during human platelet aggregation.

Platelet Aggregation in Patients with Laennec's Cirrhosis of the Liver

Mechanism of bronchoconstriction produced by thromboemboli in dogs.

Bronchoconstriction in the Presence of Pulmonary Embolism

Humoral factors in massive pulmonary embolism: An experimental study