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Biochemical Interaction Between Plants and Insects

F – Physiological Aspects of Tolerance and Physical Dependence*

An infant body plethysmograph and end‐tidal CO2, sampling were used to study respiratory CO2, response curves in newborn male infants. CO2, response curves were obtained before and after the administration of meperidine or morphine. In infants given one third the dose of each compound established to yield equivalent respiratory depression in the adult, morphine shifted the CO2, response curve to the right and downward to a greater extent than meperidine. The greater susceptibility to morphine in the infant as compared to the adult is believed to be due primarily to a greater permeability of the infant brain to morphine.

Respiratory sensitivity of the newborn infant to meperidine and morphine.

potent analgesic and a potent atropine-like substanc615. Which sort of activity predominates seems to depend, in the first place, upon the nature of substituent R of structure 1,. Analgesics have been found among compounds of the methadone type, for example I, R = COC,H,, methadols and acylated methadols, I, R = CHOR’C,H,; sulfones, I, R = SO,C,H,; esters, I, R = COOC,H, ; ketimines and acylated ketimines, I, R = C : NR’C,H,2p5*

A new series of potent analgesics

The milkweed family (Asclepiadaceae) comprises some 200 genera and 2500 species of perennial shrubs, herbs and vines distributed throughout the tropics and extending to temperate areas of the world. They include some highly prized ornamentals and economically significant weeds, and are generally characterized to the layman by the milky latex they exude when a leaf or other organ is ruptured. Chemical interest in the milkweeds has been stimulated by the use of some plants in medicinal preparations to treat cancers, tumors, and warts (Refs. in 54), as emetics, to treat bronchitis (Refs. in 64), and as a source of digitalislike therapeutic agents (Refs. in 44). They are also known for their poisonous nature, which has found advantageous use in the preparation of arrow poisons, and also causes occasional but extensive poisoning episodes among grazing sheep and cattle in milkweed-infested rangelands52,58.

Milkweed Cardenolides and Their Comparative Processing by Monarch Butterflies ( Danaus plexippus L.)

The results of pharmacologic studies with a new analgesic compound are presented. They show analgesic activity in animals with a notable lack of tolerance development and/or respiratory depression.

The Pharmacologic Effects of a New Analgesic α‐4‐Dimethylamino‐1,2‐Diphenyl‐3‐Methyl‐4‐Propionyloxybutane*

The Significance of Sugar Component in the Molecule of Cardiac Glycosides

SummaryNicotinic acid is at least several hundred times less toxic in mice, rats, and guinea pigs than nicotine. Nicotinic acid is devoid of action upon the autonomic ganglia. Nevertheless, repeated administration of large doses, 2 gm. daily, in dogs has resulted in poisoning and deaths.

E. Brown Robbins

Papers

The Pharmacologic Effects of a New Analgesic α‐4‐Dimethylamino‐1,2‐Diphenyl‐3‐Methyl‐4‐Propionyloxybutane*

The Significance of Sugar Component in the Molecule of Cardiac Glycosides

Toxicity of Nicotinic Acid

Age of animals and drug action

The Potency of Five Additional Cardiac Glucosides, Calotropin, α-Antiarin, Emicymarin, Folinerin and Sarmentocymarin*