Summary These guidelines for use of narrowband (TL-01) ultraviolet B have been prepared for dermatologists by the British Photodermatology Group on behalf of the British Association of Dermatologists. They present evidence-based guidance for treatment of patients with a variety of dermatoses and photodermatoses, with identification of the strength of evidence available at the time of preparation of the guidelines, and a brief overview of background photobiology.

An update and guidance on narrowband ultraviolet B phototherapy: a British Photodermatology Group Workshop Report

Objective : To compare the therapeutic effectiveness of daily exposure to narrowband (NB) UV-B vs broadband (BB) UV-B with and without tar. Design: Half-body exposures to NB UV-B or BB UV-B were given daily for 4 weeks in this comparative treatment study. Narrowband UV-B was delivered from TL-01 fluorescent bulbs and BB UV-B from conventional bulbs in the same phototherapy cabinet. Narrowband UV-B was compared using a paired treatment approach to BB UV-B above the waist and to BB UV-B with tar (Goeckerman treatment) below the waist. Setting: General clinical research center of a university hospital inpatient unit. Patients: Twenty-two patients with moderate-to-severe plaque-type psoriasis completed the study. main Outcome Measures: Clinical efficacy was measured weekly using psoriasis severity scoring. Therapeutic outcomes after 4 weeks were compared in paired biopsy samples from treated lesions using objective histopathological measures (quantitative reduction in epidermal acanthosis and keratin 16 expression). Results: Clinical resolution of psoriasis was achieved on 86% of paired sites treated with NB UV-B vs 73% treated with BB UV-B. Histopathological resolution of epidermal hyperplasia (marked by keratin 16 expression) was achieved in 88% of lesions treated with NB UV-B vs 59% treated with BB UV-B. Epidermal acanthosis was reduced more completely by NB UV-B treatment. Clinical resolution of psoriatic lesions occurred more rapidly following NB UV-B treatment, with some patients achieving complete resolution after 2 to 3 weeks of treatment. Conclusions: Narrowband UV-B offers a significant therapeutic advantage over BB UV-B in the treatment of psoriasis, with faster clearing and more complete disease resolution. The erythema response to NB UV-B treatment was significantly more intense and persistent compared with BB UV-B. Considerably more necrotic keratinocytes were observed in histopathological sections of skin treated with NB UV-B after a single 2.0-minimum erythema dose exposure. Treatment should be coupled with obligate minimum erythema dose testing to NB UV-B and close clinical observation during dose increases.

Narrowband UV-B produces superior Clinical and histopathological resolution of moderate-to-severe psoriasis in patients compared with broadband UV-B

Documento de consenso sobre fototerapia: terapias PUVA y UVB de banda estrecha

Background Narrow-Band ultraviolet B radiation (NB-UVB) is a relatively new treatment modality for psoriasis and many practitioners may be unaware of its effectiveness and applications. Objective The purpose of this study is to review the literature and compare NB-UVB to both broad-band ultraviolet B radiation (BB-UVB) and psoralen plus ultraviolet A radiation (PUVA) for the treatment of psoriasis and other dermatoses. Methods A comprehensive Medline search of the literature was done on all citations electronically cataloged since the mid 1960s. Results NB-UVB is superior to BB-UVB, but less effective than PUVA for the treatment of psoriasis, and is beneficial for the treatment of many other dermatoses. Conclusion NB-UVB is a useful and important adjust to the treatment of psoriasis.

Narrow-band ultraviolet B radiation: a review of the current literature.

Systemic treatments for severe pediatric psoriasis: a practical approach.

Background: Asymptomatic blisters on psoriatic plaques are an uncommon adverse effect of TL-01 (UVB narrow-band 312 nm) phototherapy. Objective: We report 7 new c

E. Candiago

Papers

Blisters on Psoriatic Lesions Treated with TL-01 Lamps