E
E D Saggerson
Researcher at University College London
Publications - 38
Citations - 1380
E D Saggerson is an academic researcher from University College London. The author has contributed to research in topics: Fatty acid synthesis & Brown adipose tissue. The author has an hindex of 21, co-authored 38 publications receiving 1355 citations.
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Journal ArticleDOI
Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation.
M. Moneeb Awan,E D Saggerson +1 more
TL;DR: It is concluded that malonyl-CoA can be synthesized within cardiac myocytes and that the level of this metabolite can be acutely regulated, likely to have consequences for the regulation of carnitine palmitoyltransferase in the heart.
Journal ArticleDOI
Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle.
N Alam,E D Saggerson +1 more
TL;DR: Etomoxir, which inhibits the mitochondrial overt form of carnitine palmitoyltransferase (CPT1), increased the tissue content of long-chain fatty acyl-CoA esters and decreased the ratio of fattyacylcarnitine to fatty Acyl- coA, suggesting that such changes could be a diagnostic for the inhibition of CPT1.
Journal ArticleDOI
The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. Effects of insulin, adrenaline and some metabolites in vitro
E D Saggerson,A. L. Greenbaum +1 more
TL;DR: Correlation of observed changes in glycolytic flux with changes in fructose 6-phosphate concentration suggested that phosphofructokinase may show regulatory behaviour, and the relative rates of production of NADPH for fatty acid synthesis by the hexose monophosphate pathway and by the ;malic enzyme' are discussed.
Journal ArticleDOI
The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. Effects of altered dietary and hormonal conditions.
E D Saggerson,A. L. Greenbaum +1 more
TL;DR: The main lesion in fatty acid synthesis in adipose tissues from starved, starved and fat-refed, and alloxan-diabetic rats appeared to reside at the level of pyruvate utilization and to be related to the rate of endogenous lipolysis, which is suggested to be regulated by the metabolism of fatty acids within the tissue.
Journal ArticleDOI
The effect of dietary and hormonal conditions on the activities of glycolytic enzymes in rat epididymal adipose tissue.
E D Saggerson,A. L. Greenbaum +1 more
TL;DR: The glycolytic enzymes of adipose tissue, unlike those of liver, were not greatly affected by the above treatments and Mechanisms for maintaining the observed relationships between the activities of the enzymes in the tissue are discussed.