These guidelines are based upon most recent and updated evidence and they are adapted to an European problematic by an expert view of the problem. These guidelines are not intended to be a meta-analysis or a systematic review. They follow the previous guidelines published in 2006 [1].

/pdf/guidelines-for-the-management-of-spontaneous-preterm-labor-qhu9vd2fir.pdf

Guidelines for the management of spontaneous preterm labor: identification of spontaneous preterm labor, diagnosis of preterm premature rupture of membranes, and preventive tools for preterm birth

Seventeen females and eight males exposed during gestation to synthetic progestins showed a significantly higher potential for physical aggression than their sex-matched unexposed siblings. Exposure to androgen-based compounds appeared to be most closely associated with aggressive responses. There were no differences in verbal aggression or IQ between exposed and unexposed siblings.

https://science.sciencemag.org/content/sci/211/4487/1171.full.pdf

Prenatal exposure to synthetic progestins increases potential for aggression in humans

Follow-up of children exposed in utero to 17 α-hydroxyprogesterone caproate compared with placebo

OBJECTIVE —Progesterone has a known diabetogenic effect. We sought to determine whether the incidence of gestational diabetes mellitus (GDM) is altered in women receiving weekly 17α-hydroxyprogesterone caproate (17P) prophylaxis for the prevention of recurrent preterm birth.

RESEARCH DESIGN AND METHODS —Singleton gestations in women having a history of preterm delivery were identified from a database containing prospectively collected information from women receiving outpatient nursing services related to a high-risk pregnancy. Included were patients enrolled for outpatient management at 28 weeks. Patients with preexisting diabetes were excluded. The incidence of GDM was compared between patients who received prophylactic intramuscular 17P (250-mg weekly injection initiated between 16.0 and 20.9 weeks' gestation) and those who did not.

RESULTS —Maternal BMI and age were similar. The incidence of GDM was 12.9% in the 17P group ( n = 557) compared with 4.9% in control subjects ( n = 1,524, P < 0.001; odds ratio 2.9 [95% CI 2.1–4.1]).

CONCLUSIONS —The use of 17P for the prevention of recurrent preterm delivery is associated with an increased risk of developing GDM. Early GDM screening is appropriate for women receiving 17P prophylaxis.

https://care.diabetesjournals.org/content/diacare/30/9/2277.full.pdf

Increased Incidence of Gestational Diabetes in Women Receiving Prophylactic 17α-Hydroxyprogesterone Caproate for Prevention of Recurrent Preterm Delivery

E E Johnstone

Papers

Assay of progestins for fetal virilizing properties using the mouse.