Pathway Profiling in Mycobacterium tuberculosis: ELUCIDATION OF CHOLESTEROL-DERIVED CATABOLITE AND ENZYMES THAT CATALYZE ITS METABOLISM *

Synthesis and structure of a biconcave cobalt perfluorophthalocyanine and its catalysis of novel oxidative carbon-phosphorus bonds formation by using air.

Methods for treating and preventing obesity, inhibiting adipocyte differentiation, inhibiting increased SCD-1 gene transcription, and/or reducing body fat in a subject include administering at least one analog of 1a,25-dihydroxyvitamin D3 or 1a,25-dihydroxyvitamin D2 or a pharmaceutical composition that includes such an analog to a subject in need thereof. The analog may be a 19-nor vitamin D analog such as a compound of formula IA, a compound of formula IB, or a mixture thereof where the variables R1, R2, and R3 have the values described herein.

Vitamin D analogs for obesity prevention and treatment

Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms; straight or branched chain alkenyl groups having from 2 to 8 carbon atoms; straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms; straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.

E. Mincione

Papers

Improved Conversion of Vitamin D2 into the Windaus Ketone and Its Regioselective Hydroxylation Via Organoboranes at C26

The Preparation of 1-Silyl, β-Allehyl Alcohols, Useful Synthetic Intermediates.