Publisher Summary This chapter discusses crystal structures of metal–peptide complexes. Most of the crystal-structure analyses of metal–amino acid and metal–peptide complexes have been carried out on the assumption that such complexes act as models for the metal-binding sites on proteins. Crystal-structure analyses show that the geometrical features of metal complexes of amino acids, peptides and imidazole are related in systematic ways to the chemical structure, which the complexes have in the crystalline state. Moreover, the transfer of geometrical information from crystal-structure analyses to species that exist in solution depends on the assumption that the complexes found in crystals are present also in the solutions from which the crystals grow. This chapter illustrates that, the existence of cis-trans isomers coordination isomers, optical isomers, and dimeric species in the crystalline complexes emphasizes the variety of species, which must be considered when equations are written to represent metal–peptide equilibria in solution.

Crystal structures of metal-peptide complexes.

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