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Recent developments in isocyanide based multicomponent reactions in applied chemistry

Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds. With a small set of starting materials, very large libraries can be built up within a short time, which can then be used for research on medicinal substances. Due to the intensive research of the last few years, many new backbone types have become accessible. MCRs are also increasingly being employed in the total synthesis of natural products. MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures. However, this requires that the chemist learns the “language” of MCRs, something that this review wishes to stimulate.

Multicomponent Reactions with Isocyanides.

N-Heterocyclic carbenes have become universal ligands in organometallic and inorganic coordination chemistry. They not only bind to any transition metal, be it in low or high oxidation states, but also to main group elements such as beryllium, sulfur, and iodine. Because of their specific coordination chemistry, N-heterocyclic carbenes both stabilize and activate metal centers in quite different key catalytic steps of organic syntheses, for example, C-H activation, C-C, C-H, C-O, and C-N bond formation. There is now ample evidence that in the new generation of organometallic catalysts the established ligand class of organophosphanes will be supplemented and, in part, replaced by N-heterocyclic carbenes. Over the past few years, this chemistry has been the field of vivid scientific competition, and yielded previously unexpected successes in key areas of homogeneous catalysis. From the work in numerous academic laboratories and in industry, a revolutionary turning point in oraganometallic catalysis is emerging.

http://aether.cmi.ua.ac.be/artikels/Artikels%20Gitte/Artikels/Reviews/NHC-%20liganden%20Herrmann.pdf

N-heterocyclic carbenes: a new concept in organometallic catalysis.

Self-Assembly of Discrete Cyclic Nanostructures Mediated by Transition Metals

Oxidative Addition von Tellurwasserstoff an Organometallfragmente

Eine neue Methode zur Synthese amphipolarer Phosphorheterocyclen

Mehrfachbindungen zwischen hauptgruppenelementen und übergangsmetallen: XXI. Zur oxophilie höhervalenter organorheniumfragmente: Synthese und molekülstruktur neuartiger (η5-C5Me5)ReO3- und (η5-C5Me5)ReO4-komplexe

Mehrfachbindungen zwischen Hauptgruppenelementen und Übergangsmetallen: LXI. Darstellung und Strukturaufklärung von schwefelund sauerstoffhaltigen Organovanadium(V)-Komplexen

Eberhardt Herdtweck

Papers

Oxidative Addition von Tellurwasserstoff an Organometallfragmente

Eine neue Methode zur Synthese amphipolarer Phosphorheterocyclen

Mehrfachbindungen zwischen hauptgruppenelementen und übergangsmetallen: XXI. Zur oxophilie höhervalenter organorheniumfragmente: Synthese und molekülstruktur neuartiger (η5-C5Me5)ReO3- und (η5-C5Me5)ReO4-komplexe

Mehrfachbindungen zwischen Hauptgruppenelementen und Übergangsmetallen: LXI. Darstellung und Strukturaufklärung von schwefelund sauerstoffhaltigen Organovanadium(V)-Komplexen

Alkinkomplexe von Rhenium in mittleren Oxidationsstufen; Synthesen und Molekülstruktur eines Rhenium(V)‐allyliden‐Komplexes