E
Edson X. Albuquerque
Researcher at Federal University of Rio de Janeiro
Publications - 16
Citations - 2115
Edson X. Albuquerque is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Nicotinic agonist & Acetylcholine. The author has an hindex of 8, co-authored 16 publications receiving 2061 citations.
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Journal ArticleDOI
The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications
Corey Hilmas,Edna F. R. Pereira,Manickavasagom Alkondon,Arash Rassoulpour,Robert Schwarcz,Edson X. Albuquerque +5 more
TL;DR: It is demonstrated that nAChRs are targets for KYNA and suggest a functionally significant cross talk between the nicotinic cholinergic system and the kynurenine pathway in the brain.
Journal Article
Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.
TL;DR: Differences observed in the pharmacological and functional properties of the Nicotinic currents imply the expression of at least three structurally distinct nicotinic acetylcholine receptor subtypes in hippocampal neurons, which may involvement in the transduction of signals is discussed.
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Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices.
TL;DR: It is demonstrated that CA1 interneurons, in addition to expressing functional α7 nA ChRs, also express functional α4β2-like nAChRs and that activation of both receptors facilitates an action potential-dependent release of GABA.
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Nicotinic Receptor Activation in Human Cerebral Cortical Interneurons: a Mechanism for Inhibition and Disinhibition of Neuronal Networks
TL;DR: The discovery of functional nicotinic receptors (nAChRs) in interneurons of the human cerebral cortex is reported and these mechanisms can account for the involvement of nA ChRs in cognitive functions and in certain neuropathological conditions.
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Initial characterization of the nicotinic acetylcholine receptors in rat hippocampal neurons
TL;DR: The present results demonstrate the existence of an inwardly rectifying, snake neurotoxin-sensitive functional nicotinic acetylcholine receptor ion channel in rat hippocampal neurons.