Showing papers by "Edward J. Holland published in 1987"
TL;DR: Although chronic eye disease, including keratoconus, did have an impact on personality functioning in young and middle-aged adults, no specific complex of personality characteristics attributable to keratconus could be identified.
Abstract: • Patients with keratoconus frequently are described as having peculiar personality characteristics, despite the lack of controlled studies in the ophthalmologic or psychiatric literature. We studied 109 subjects, using a standardized personality inventory (the Millon Clinical Multiaxial Inventory) that measures 20 personality scales—both normal and pathologic. Subjects were divided into three agematched groups: (1) patients with keratoconus, (2) patients with other chronic eye diseases, and (3) normal controls. Results indicated that although chronic eye disease, including keratoconus, did have an impact on personality functioning in young and middle-aged adults, no specific complex of personality characteristics attributable to keratoconus could be identified. Patients with keratoconus differed from normal controls in much the same way as did patients with other chronic eye diseases, being less conforming and more passive-aggressive, paranoid, and hypomanic. They tended to more disorganized patterns of thinking and scored higher on substance abuse indicators. The influence of keratoconus on personality may be a function of the timing and nature of its onset in the context of the patient's psychosocial development.
60 citations
TL;DR: It is demonstrated that most corneas preserved in organ culture at 34 degrees C do not contain Langerhans cells at the time of transplantation.
Abstract: • We examined the effect of corneal preservation in organ culture at 34°C on Langerhans cells in murine and human corneas. The presence of Langerhans cells was demonstrated by an adenosine triphosphatase stain. Langerhans cells were identified on fresh corneas and on corneas that had been in organ culture for one week or less. However, Langerhans cells were not found on most corneas after the second to third week in culture. The absence of Langerhans cells was found to be directly related to the condition of the corneal epithelium. During the second and occasionally as late as the third week in culture, the superficial layers of epithelium are sloughed. Examination of the corneas lacking Langerhans cells disclosed Langerhans cells in the sloughed epithelium. The results demonstrate that most corneas preserved in organ culture at 34°C do not contain Langerhans cells at the time of transplantation.
29 citations