E
Elaine E. Hamm
Researcher at University of Oklahoma Health Sciences Center
Publications - 8
Citations - 228
Elaine E. Hamm is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Clostridium difficile toxin B & Zebrafish. The author has an hindex of 5, co-authored 8 publications receiving 217 citations. Previous affiliations of Elaine E. Hamm include University of Oklahoma.
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Journal ArticleDOI
Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication
TL;DR: In line with the observed defects in ventricle contraction, TcdB was found to directly disrupt coordinated contractility and rhythmicity in primary cardiomyocytes and using a caspase-3 inhibitor, was able to block TCDB-related cardiovascular damage and prevent zebrafish death.
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Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity.
Daniel E. Voth,Elaine E. Hamm,Lan G. Nguyen,Amy E. Tucker,Isabelle I. Salles,William Ortiz-Leduc,Jimmy D. Ballard +6 more
TL;DR: Analysis of zebrafish embryos and specific cell lines suggested OT is cytotoxic in a cell‐dependent manner and may contribute to disease through direct cell killing leading to tissue necrosis.
Journal ArticleDOI
Regulatory Interactions of a Virulence-Associated Serine/Threonine Phosphatase-Kinase Pair in Bacillus anthracis
Salika M. Shakir,Katie M. Bryant,Jason L. Larabee,Elaine E. Hamm,Julie A. Lovchik,C. Rick Lyons,Jimmy D. Ballard +6 more
TL;DR: Insight is provided into a previously undescribed Stp/Stk pair in B. anthracis, which is a PP2C phosphatase and dephosphorylates phosphoserine and phosphothreonine residues and can be influenced by BA-Stp1 deph phosphorylation.
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The Mechanism of Bacillus anthracis Intracellular Germination Requires Multiple and Highly Diverse Genetic Loci
Soumitra Barua,Matthew T. McKevitt,Kevin DeGiusti,Elaine E. Hamm,Jason L. Larabee,Salika M. Shakir,Katie M. Bryant,Theresa M. Koehler,Steven R. Blanke,David W. Dyer,Allison F. Gillaspy,Jimmy D. Ballard +11 more
TL;DR: Insight is provided into the mechanisms supporting B. anthracis germination within host cells and a mechanism wherein the intergenic region between BAs 2807 and BAs2808 has a global affect on germination of this pathogen.
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Clostridium sordellii Lethal Toxin Is Maintained in a Multimeric Protein Complex
TL;DR: It is suggested that Clostridium sordellii lethal toxin is maintained in a protease-resistant, high-molecular-weight complex, which dissociates at pH 4.0, leading to cytotoxicity.