Elke Laedtke

TL;DR: Findings show that tightly regulated control of proteasomal proteolysis of a specific protein alone can play a pivotal role in neural regulation.

TL;DR: The results underline the pivotal role of norepinephrine for the regulation of pineal signal transduction, but they also support the notion that other neurotransmitters and neuropeptides are involved in the modulation of Pineal calcium signalling.

TL;DR: Results indicate that the stimulatory effects of VIP and PACAP on rat pinealocytes involve phosphorylation of transcription factors of the CREB family as holds also true for NE, which conforms to previous results showing that both neuropeptides are also less effective than NE in stimulating the melatonin biosynthesis in the rat Pineal organ.

TL;DR: The study reveals that discrete differences in pineal signal transduction exist between the cow and rodent, and emphasizes the potential importance that the analysis of ungulate pinealocytes may play in understanding regulation of pineal melatonin biosynthesis in primates and man.

TL;DR: The first anatomical, molecular biological, and ethological data on the organization of the circadian system of a lancelet, Branchiostoma lanceolatum, suggest a homology of the amphiPer expessing cells to the suprachiasmatic nucleus of vertebrates.