E
Ella Kim
Researcher at Boston Children's Hospital
Publications - 4
Citations - 490
Ella Kim is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Mutant & Gene. The author has an hindex of 4, co-authored 4 publications receiving 446 citations.
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Journal ArticleDOI
MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity.
Nadiya M. Teplyuk,Brit Mollenhauer,Galina Gabriely,Alf Giese,Ella Kim,Michael Smolsky,Ryan Y. Kim,Marlon Garzo Saria,Sandra Pastorino,Santosh Kesari,Anna M. Krichevsky +10 more
TL;DR: This study demonstrates that microRNA-based detection of brain malignancies can be reliably performed and that microRNAs in CSF can serve as biomarkers of treatment response in brain cancers.
Journal ArticleDOI
Transcriptional activities of mutant p53: When mutations are more than a loss
Ella Kim,Wolfgang Deppert +1 more
TL;DR: Systematic analyses of the transcriptional activities of mutant p53 suggest that not the loss of transcriptional activity as such, but alterations of target DNA selectivity may be the driving force of mutants p53 specific transcription underlying the growth‐promoting effects of mutantp53.
Journal ArticleDOI
Mutant p53 proteins bind DNA in a DNA structure-selective mode.
TL;DR: It is proposed that DNA structure-selective binding of mutp53 proteins is the basis for the well-documented interaction ofmutp53 with MAR elements and for transcriptional activities mediates by mutp 53.
Journal ArticleDOI
Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1
Ella Kim,Willy Günther,Kimio Yoshizato,Hildegard Meissner,Srenja Zapf,Rolf M Nüsing,Hirotaka Yamamoto,Erwin G. Van Meir,Wolfgang Deppert,Alf Giese +9 more
TL;DR: It is shown that ets-1 and p53 associate physically in vitro and in vivo and that their interaction, rather than a direct binding of p53 to the TXSA promoter, is required for transcriptional repression of TXSA by wild-type p53.