E
Erin E. Congdon
Researcher at New York University
Publications - 14
Citations - 1132
Erin E. Congdon is an academic researcher from New York University. The author has contributed to research in topics: Tau protein & Antibody. The author has an hindex of 8, co-authored 10 publications receiving 782 citations.
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Journal ArticleDOI
Tau-targeting therapies for Alzheimer disease.
TL;DR: Therapies for Alzheimer disease in clinical trials are gradually shifting from amyloid-β (Aβ)-targeting to tau-targeting approaches, and tau is likely to be a better target than Aβ once cognitive deficits manifest because the tau burden correlates better with clinical impairments than does the Aβ burden.
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Antibody Uptake into Neurons Occurs Primarily via Clathrin-dependent Fcγ Receptor Endocytosis and Is a Prerequisite for Acute Tau Protein Clearance
TL;DR: Findings clarify that Tau antibody uptake is primarily receptor-mediated, that these antibodies are mainly found in neurons with Tau aggregates, and that their intracellular interaction leads to clearance of Tau pathology, all of which have major implications for therapeutic development of this approach.
Journal ArticleDOI
Two Novel Tau Antibodies Targeting the 396/404 Region Are Primarily Taken Up by Neurons and Reduce Tau Protein Pathology
TL;DR: Fc-receptor-mediated endocytosis and the endosome/autophagosome/lysosome system are likely to have a critical role in antibody-mediated clearance of Tau pathology.
Journal ArticleDOI
Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease.
TL;DR: It is proposed that sex-based differences in autophagy regulation during the lifespan contribute to the increased risk of AD, and greater severity of pathology seen in women.
Journal ArticleDOI
Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.
Erin E. Congdon,Yan Lin,Hameetha B. Rajamohamedsait,Dov B. Shamir,Senthilkumar Krishnaswamy,Wajitha J. Rajamohamedsait,Suhail Rasool,Veronica Gonzalez,Josien Levenga,Josien Levenga,Jiaping Gu,Charles A. Hoeffer,Charles A. Hoeffer,Einar M. Sigurdsson +13 more
TL;DR: Overall, these findings indicate that high antibody affinity for solubilized PHF predicts efficacy, and that acute antibody-mediated improvement in cognition relates to clearance of soluble phospho-tau.