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Esmée Vendel
Researcher at Leiden University
Publications - 7
Citations - 137
Esmée Vendel is an academic researcher from Leiden University. The author has contributed to research in topics: Pharmacokinetics & Internal medicine. The author has an hindex of 3, co-authored 6 publications receiving 89 citations.
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The need for mathematical modelling of spatial drug distribution within the brain
TL;DR: There is a need for a more comprehensive and integrated model that fills the current gaps in predicting the local drug distribution within the brain, according to system-specific and drug-specific properties that affect the local distribution of drugs in the brain.
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Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrier.
TL;DR: It is demonstrated that both CB receptors are able to restore the BBB and neuroprotection, but much uncertainty about the underlying signaling cascades still exists and further investigation is needed.
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Improving the Prediction of Local Drug Distribution Profiles in the Brain with a New 2D Mathematical Model
TL;DR: A new model for a 2D square brain tissue unit, consisting of brain extracellular fluid (ECF) that is surrounded by the brain capillaries, is developed and the change in free drug concentration within the brain ECF is described by a partial differential equation (PDE).
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The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions
TL;DR: The 3D brain unit network model is demonstrated to be an excellent tool to gain understanding in the interdependencies of the factors governing spatial-temporal drug concentrations within the brain ECF and helps in predicting the spatial-Temporal brainECF concentrations of existing drugs, under both normal and disease conditions.
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A 3D brain unit model to further improve prediction of local drug distribution within the brain.
TL;DR: A 3D brain unit model is developed, which builds on the previous proof-of-concept 2Dbrain unit model, to understand the factors that govern local unbound and bound drug PK within the brain.