Esther Arman

TL;DR: It is suggested that FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass and the possibility that this activity is mediated by FGF4 signals transmitted byFGFR2 is raised.

TL;DR: Exposure of both FGFR2 variants is concordant with their involvement in murine gastrulation, and it is suggested that alternative splicing is jointly responsible for ligand binding and spatial specificity.

TL;DR: Fusion chimeras demonstrated that early lethality was indeed because of trophectoderm defects and indicated that in the embryonic cell lineages Fgfr2 activity manifests in limb and lung development.

TL;DR: It is demonstrated that the basement membrane is required for embryoid body differentiation by rescuing columnar ectoderm differentiation and cavitation in the mutant by externally added basement membrane proteins, providing a new paradigm for the role of fibroblast growth factor signaling in basement membrane formation and epithelial differentiation.

TL;DR: It is demonstrated that pluripotent ES cells display laminin receptors; hence, these stem cells may serve as target for columnar ectoderm differentiation, and pharmacological and dominant-negative inhibitors reveal that the cell shape change of epiblast differentiation requires ROCK, the Rho kinase.