This 11th edition of the book Modern Nutrition in Health and Disease, featuring the work of more than 190 expert authors and divided into five parts, fully explains and encapsulates the fundamentals of nutrition and its role in contemporary society, from mastering the basic science of nutrient metabolism and function to applying nutritional concepts to combat human disease. Part I comprehensively covers specific dietary components, including major dietary constituents, minerals, vitamins and other Other CABI sites 

Modern Nutrition in Health and Disease

Objective: To examine the relation between serum levels of homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12, and risk of incident Alzheimer disease (AD) in a sample of Finnish community-dwelling elderly. Methods: A dementia-free sample of 271 subjects aged 65–79 years derived from the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study was followed up for 7 years to detect incident AD. The association between serum tHcy and holoTC with AD was analyzed with multiple logistic regression after adjusting for several potential confounders, including common vascular risk factors. Results: The odds ratios (ORs) (95% confidence interval [CI]) for AD were 1.16 (1.04–1.31) per increase of 1 μmol/L of tHcy at baseline and 0.980 (0.965–0.995) for each increase of 1 pmol/L baseline holoTC. Adjustment for several potential confounders including age, sex, education, APOE ϵ4 allele, body mass index, Mini-Mental State Examination, smoking, stroke, and blood pressure did not alter the associations: ORs (95% CI) for AD became 1.19 (1.01–1.39) for tHcy and 0.977 (0.958–0.997) for holoTC. Adjusting for holoTC attenuated the tHcy–AD link (OR changed from 1.16 to 1.10, 95% CI 0.96–1.25). The holoTC–AD relationship was less influenced by controlling for tHcy (OR changed from 0.980 to 0.984, 95% CI 0.968–1.000). Addition of folate did not change any of the results. Conclusions: This study suggests that both tHcy and holoTC may be involved in the development of AD. The tHcy–AD link may be partly explained by serum holoTC. The role of holoTC in AD should be further investigated.

Homocysteine and holotranscobalamin and the risk of Alzheimer disease A longitudinal study

On megaloblastic anemia

As COVID-19 disease escalates globally, optimising patient outcome during this catastrophic healthcare crisis is the number one priority. The principles of patient blood management are fundamental strategies to improve patient outcomes and should be given high priority in this crisis situation. The aim of this expert review is to provide clinicians and healthcare authorities with information regarding how to apply established principles of patient blood management during the COVID-19 pandemic. In particular, this review considers the impact of the COVID-19 pandemic on blood supply and specifies important aspects of donor management. We discuss how preventative and control measures implemented during the COVID-19 crisis could affect the prevalence of anaemia, and highlight issues regarding the diagnosis and treatment of anaemia in patients requiring elective or emergency surgery. In addition, we review aspects related to patient blood management of critically ill patients with known or suspected COVID-19, and discuss important alterations of the coagulation system in patients hospitalised due to COVID-19. Finally, we address special considerations pertaining to supply-demand and cost-benefit issues of patient blood management during the COVID-19 pandemic.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/anae.15095

Patient blood management during the COVID-19 pandemic: a narrative review.

Recently, attention has been drawn to the fact that increasing the consumption of edible insects may positively impact the state of the natural environment and reduce the problem of malnutrition in large parts of society Indeed, insects are seen as an alternative to traditional meat products, primarily meat This article aimed to compare the nutritional value of edible insects and meat Based on tables of composition and nutritional value and on the licensed computer program Diet 6D, data on the nutritional value of 10 commonly consumed meat types were compiled Based on a literature review, data on the nutritional value of seven commercially available edible insect species were collected and collated There was a comparison of 100 g of edible insects with 100 g of meat (fresh weight) In addition, the atherogenic index thrombogenic index, the hypocholesterolemic/hypercholesterolemic ratio, and the nutritional quality index were calculated It was found that both meat and insects are rich in nutrients, including those considered essential for the proper development and functioning of the human body At the same time, it has been shown that the content of individual nutrients in both insects and meat varies significantly

Edible Insects versus Meat-Nutritional Comparison: Knowledge of Their Composition Is the Key to Good Health.

Vitamins and minerals are essential to humans as they play essential roles in a variety of basic metabolic pathways that support fundamental cellular functions. In particular, their involvement in energy-yielding metabolism, DNA synthesis, oxygen transport, and neuronal functions makes them critical for brain and muscular function. These, in turn, translate into effects on cognitive and psychological processes, including mental and physical fatigue. This review is focused on B vitamins (B1, B2, B3, B5, B6, B8, B9 and B12), vitamin C, iron, magnesium and zinc, which have recognized roles in these outcomes. It summarizes the biochemical bases and actions of these micronutrients at both the molecular and cellular levels and connects them with cognitive and psychological symptoms, as well as manifestations of fatigue that may occur when status or supplies of these micronutrients are not adequate.

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

Objectives
Vitamins and minerals dietary intake recommendations rely on their role on energy-yielding metabolism, cognitive functions and fatigue relief. However, even in adult populations, reliable information on the actual dietary intake is not easily available. In this study, possible gaps between recommendation and actual intake of these micronutrients were assessed in adult European (Spain &Turkey), American (USA, Brazil & Mexico) and Asian (Vietnam) populations. It aimed to provide an overview of the risk of inadequate intake and to identify potential variations across geographic regions and genders.


Methods
In each country, information was retrieved from representative nation-wide dietary survey, government reports and Medline scientific publications. Prevalence of inadequate intake was classified as the proportion of the population group with an intake below the estimated average requirement (EAR) as follows: <15%: low risk (green); 15 to 40%: possible risk (yellow); 41 to 75%: real risk (orange); >75%: high risk (red).


Results
The risk of inadequate intake of micronutrients known for their role on physical and mental performance varied across nutrients, genders and countries (Table 1). Some common features were identified across the six countries such as a higher risk of deficiency in women compared to men and in developing vs developed countries. Certain specific risks were identified namely a high risk of inadequate folate intake in Spain, a wide geographical risk of inadequate vitamin C intake even where fruits should be easily available, and a general risk for most micronutrients in Turkey.


Conclusions
Inadequate dietary intakes are far from being uncommon in most countries in the selected micronutrients that are key for the energy metabolism, cognitive functions and fatigue relief. Therefore, diets and nutritional education need constant improvement worldwide, and dietary supplements could be helpful by closing the gaps between the recommended and the actual intakes.


Funding Sources
This study has been sponsored by Sanofi.


Supporting Tables Images and/or Graphs

Adult's Dietary Intakes of Selected Vitamins & Minerals Essential for Energy Metabolism and Cognition: A Comparison Across Countries & Genders (FS10-04-19)

Background: Unexplained fatigue is a common complaint. When underlying disease causes have been eliminated, lifestyle measures and supplementation can be indicated. Elaborating on clinical findings that G115®, a dry extract from the root of Panax ginseng, combined with vitamins and minerals could alleviate fatigue, this open label study aimed at assessing its effect on perceived fatigue and energy. Methods: Healthy adults self-reporting fatigue (n = 103) completed the Multidimensional Fatigue Inventory questionnaire. They rated their perceptions of mental and physical fatigue, energy, performance, and stress at baseline and 15, 30, 60 and 90 days after a daily intake of 40 mg G115® formulated with vitamins and minerals. Results: Compared with baseline values, mean self-perception of general fatigue was reduced by −7.55 units [95% CI: −8.44; −6.66] (−41.8%, p < 0.0001) at 90 days. All assessed perception ratings (mental and physical fatigue, reduced activity and motivation, performance, and stress) were significantly and steadily improved from two weeks after supplementation up to study’s end. Overall satisfaction with the ability of the product to reduce fatigue reached 85% at Day 90. Conclusion: Daily intake with G115® extract formulated with vitamins and minerals suggests an improvement of self-perception of fatigue and energy in a fatigued adult population.

/pdf/reduced-self-perception-of-fatigue-after-intake-of-panax-3ksce1nzcl.pdf

Etienne Pouteau

Papers

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

Adult's Dietary Intakes of Selected Vitamins & Minerals Essential for Energy Metabolism and Cognition: A Comparison Across Countries & Genders (FS10-04-19)

Reduced Self-Perception of Fatigue after Intake of Panax ginseng Root Extract (G115®) Formulated with Vitamins and Minerals-An Open-Label Study.