Eugenia Niculescu-Morzsa

TL;DR: This study implies that high-molecular-weight HA has a chondroprotective effect in the present co-cultivation inflammation model, as it decreases pro-inflammatory cytokines and increases anabolic factors.

TL;DR: The chick chorioallantoic membrane (CAM) model is used to monitor the vascular reaction to sample bone chips representing the respective procedural steps of bone grafting to determine which step of this procedure diminishes the ability of allografts to induce or promote vascularisation.

TL;DR: PRP can replace standard usage of FCS for chondrogenic priming and expansion as implications for clinical use such as ACI procedures and enhances both proliferation and redifferentiation of dedifferentiated chondrocytes.

TL;DR: Evaluating the impact of the mRNA levels of transcription factors on the expression of cartilage-specific structural genes might contribute to a better understanding of the transcriptional regulation of structural gene expression of chondrocytes with implications for their use in matrix-assisted autologous chondROcyte implantation.

TL;DR: Mid-term intermitted mechanical stimulation in vitro has the potential to improve the cell quality of cell matrix constructs prepared from dedifferentiated osteoarthritic chondrocytes and confirms the importance of moderate dynamic compression in clinical rehabilitation after MACI.