E
Evan J. Horn
Researcher at Scripps Research Institute
Publications - 7
Citations - 1230
Evan J. Horn is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Intramolecular reaction & Flash vacuum pyrolysis. The author has an hindex of 5, co-authored 7 publications receiving 951 citations. Previous affiliations of Evan J. Horn include University of California, Davis & University of California, Irvine.
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Journal ArticleDOI
Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method
TL;DR: In this Outlook, illustrative examples of electrochemical reactions in the context of the synthesis of complex molecules are highlighted, showcasing the intrinsic benefits of electro chemical reactions versus traditional reagent-based approaches.
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Scalable and sustainable electrochemical allylic C–H oxidation
TL;DR: This work describes an electrochemical C–H oxidation strategy that exhibits broad substrate scope, operational simplicity and high chemoselectivity, and represents a scalable allylic C-H oxidation (demonstrated on 100 grams), enabling the adoption of this C–h oxidation strategy in large-scale industrial settings without substantial environmental impact.
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Investigation into an efficient synthesis of 2,3-dehydro-N-acetyl neuraminic acid leads to three decarboxylated sialic acid dimers.
TL;DR: Six compounds, including three new decarboxylated sialic acid dimers, were also found to have been synthesized in the reaction, and all of the side products were isolated and fully characterized.
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A Failed Late-Stage Epimerization Thwarts an Approach to Ineleganolide.
TL;DR: While the two key enantioenriched building blocks were made via high-yielding sequences and their convergent union was efficient, the critical C4-C5 bond of this sterically congested natural product could never be forged.
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Efficient method for the preparation of peracetylated Neu5Ac2en by flash vacuum pyrolysis.
TL;DR: Mechanistic evidence including deuterium labeled studies and DFT (B3LYP) calculations suggest this transformation proceeds via an intramolecular syn-elimination.