Evelyn Smith

TL;DR: It is suggested that weight gain results, at least in part, from a neurological predisposition characterized by reduced executive function, and in turn obesity itself has a compounding negative impact on the brain via mechanisms currently attributed to low‐grade systemic inflammation, elevated lipids and/or insulin resistance.

TL;DR: Arterial stiffness is associated with cerebral small vessel disease and decreased cognitive function, however methodological limitations such as differing covariates between studies and an over-reliance on the MMSE to measure cognition are a concern across much of the literature.

TL;DR: In this paper, the cross-sectional relationships between markers of systemic inflammation (C-reactive protein, interleukins-1β, -6, -8, -10, -12, plasminogen activator inhibitor, serum amyloid A, tumour necrosis factor-α and vascular adhesion molecule-1) and cognitive function in 873 non-demented community-dwelling elderly participants aged 70-90 years were examined.

TL;DR: The results show a significant linear relationship between increasing levels of IL-6 and depressive symptoms at baseline only, whereas IL-8 was associated with depressed Symptoms at baseline and at 2 years follow-up, and PAI-1 could be regarded as a marker of remitted depression.

TL;DR: The findings suggest an association between specific inflammatory markers and MCI subtypes, highlight sex differences in the association with MCI, and point to a discrete impact of systemic inflammation on cognition.