F D'Onofrio

TL;DR: The results show that acute hyperglycemia in normal subjects causes significant hemodynamic and rheological changes that are reversed by L-arginine, which suggests that hyper glycemia may reduce nitric oxide availability in humans.

TL;DR: In this article, the authors compared the metabolic and cardiovascular effects of carvedilol with those of atenololol in diabetic patients with hypertension, and found that the effect of carvingilol was greater than those of the other drugs, as follows: increase in total glucose disposal, 9.54μmol/kg of body weight per minute (95% Cl, 7 to 11.9 μmol/ kg per minute); decrease in plasma glucose response to oral glucose, 61 mmol/L x 180 minutes (Cl, -101 to -21 mmol/l x 180

TL;DR: Fasting glucose, HbA1c, fasting and glucose-stimulated insulin, blood pressure and left ventricular mass, cholesterol, triglycerides, and fibrinogen decreased significantly after metformin treatment, whereas high-density lipoprotein cholesterol increased.

TL;DR: Findings show that systemic infusion of L-arginine in healthy subjects induces vasodilation and inhibits platelet aggregation and blood viscosity and are mediated, in part, by endogenous released insulin.

TL;DR: The polyol pathway is implicated in hemodynamic changes associated with early diabetic nephropathy, and aldose reductase treatment can positively influence these parameters.